RUNX2 binds GLI3R

Stable Identifier
R-HSA-9008215
Type
Reaction [binding]
Species
Homo sapiens
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Based on studies in mice, GLI3R, a repressive form of GLI3 generated in the Hedgehog "off" state, binds to RUNX2 and inhibits binding of RUNX2 to DNA. Cells haploinsufficient for PTCH1 generate less GLI3R, which is associated with increased RUNX2 activity and accelerated osteoblast differentiation (Ohba et al. 2008).

Literature References
PubMed ID Title Journal Year
18477452 Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

Ohba, S, Kawaguchi, H, Kugimiya, F, Ogasawara, T, Kawamura, N, Saito, T, Ikeda, T, Fujii, K, Miyajima, T, Kuramochi, A, Miyashita, T, Oda, H, Nakamura, K, Takato, T, Chung, UI

Dev. Cell 2008
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