Reactome | Interleukin-9 signaling

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Interleukin-9 signaling Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
created	[InstanceEdit:8985906] Duenas, Corina, 2017-04-21
crossReference	[DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819649] BioModels Database:BIOMD0000000968 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	8985947
displayName	Interleukin-9 signaling
doi	10.3180/R-HSA-8985947.4
edited	[InstanceEdit:9005914] Jupe, Steve, 2017-05-11 [InstanceEdit:9607062] Jassal, Bijay, 2018-04-27
eventOf	[Pathway:R-HSA-451927] Interleukin-2 family signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2266260] interleukin-9-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-451895] IL2RG binds JAK3 - Homo sapiens [Reaction:R-HSA-9679028] JAK3 binds JAK3 inhibitors - Homo sapiens [Reaction:R-HSA-9011748] IL9R binds JAK1 - Homo sapiens [Reaction:R-HSA-8963734] IL9 binds IL9R:JAK1 and IL2RG:JAK3 - Homo sapiens [BlackBoxEvent:R-HSA-8985914] IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 - Homo sapiens [BlackBoxEvent:R-HSA-8985973] IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 - Homo sapiens [Reaction:R-HSA-8985929] IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B - Homo sapiens [Reaction:R-HSA-8985988] IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 - Homo sapiens [BlackBoxEvent:R-HSA-8985900] p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 - Homo sapiens [Reaction:R-HSA-8985943] p-Y701-STAT1 dimerizes - Homo sapiens [BlackBoxEvent:R-HSA-8985950] p-Y694-STAT5A, p-STAT5B dimerizes - Homo sapiens [Reaction:R-HSA-8985966] p-Y701-STAT1 binds p-Y705-STAT3 - Homo sapiens [BlackBoxEvent:R-HSA-8985981] p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:8985937] IL-9 signaling as key driver of chronic inflammation in mucosal immunity [LiteratureReference:8985958] IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity [LiteratureReference:8985956] Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Interleukin-9 signaling
orthologousEvent	[Pathway:R-DDI-8985947] Interleukin-9 signaling - Dictyostelium discoideum [Pathway:R-CEL-8985947] Interleukin-9 signaling - Caenorhabditis elegans [Pathway:R-DME-8985947] Interleukin-9 signaling - Drosophila melanogaster [Pathway:R-GGA-8985947] Interleukin-9 signaling - Gallus gallus [Pathway:R-XTR-8985947] Interleukin-9 signaling - Xenopus tropicalis [Pathway:R-DRE-8985947] Interleukin-9 signaling - Danio rerio [Pathway:R-SSC-8985947] Interleukin-9 signaling - Sus scrofa [Pathway:R-BTA-8985947] Interleukin-9 signaling - Bos taurus [Pathway:R-CFA-8985947] Interleukin-9 signaling - Canis familiaris [Pathway:R-RNO-8985947] Interleukin-9 signaling - Rattus norvegicus [Pathway:R-MMU-8985947] Interleukin-9 signaling - Mus musculus
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28 [InstanceEdit:9607063] Limon, Paula, 2018-04-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8985947
summation	[Summation:8986003] Interleukin 9 (IL9) binds interleukin 9 receptor a chain (...
updateTrackers	[UpdateTracker:9779435] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v65:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9778406] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v68:[updateContainedRLE] [UpdateTracker:9780790] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v62:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9776732] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9846597] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v84:[updateContainedRLE] [UpdateTracker:9910934] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v89:[updateContainedRLE] [UpdateTracker:9780230] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v63:[modifyText, updateContainedRLE]

Referrals

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[Pathway:R-HSA-451927] Interleukin-2 family signaling

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