Reactome | Interleukin-9 signaling

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Interleukin-9 signaling Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444750
displayName	Interleukin-9 signaling
eventOf	[Pathway:R-BTA-451927] Interleukin-2 family signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2266260] interleukin-9-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-451895] IL2RG binds JAK3 - Bos taurus [Reaction:R-BTA-9679028] JAK3 binds JAK3 inhibitors - Bos taurus [Reaction:R-BTA-9011748] IL9R binds JAK1 - Bos taurus [Reaction:R-BTA-8963734] IL9 binds IL9R:JAK1 and IL2RG:JAK3 - Bos taurus [BlackBoxEvent:R-BTA-8985914] IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 - Bos taurus [BlackBoxEvent:R-BTA-8985973] IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 - Bos taurus [Reaction:R-BTA-8985929] IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B - Bos taurus [Reaction:R-BTA-8985988] IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 - Bos taurus [BlackBoxEvent:R-BTA-8985900] p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 - Bos taurus [Reaction:R-BTA-8985943] p-Y701-STAT1 dimerizes - Bos taurus [BlackBoxEvent:R-BTA-8985950] p-Y694-STAT5A, p-STAT5B dimerizes - Bos taurus [Reaction:R-BTA-8985966] p-Y701-STAT1 binds p-Y705-STAT3 - Bos taurus [BlackBoxEvent:R-BTA-8985981] p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus - Bos taurus
inferredFrom	[Pathway:R-HSA-8985947] Interleukin-9 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-9 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-8985947
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-451927] Interleukin-2 family signaling
(inferredTo)	[Pathway:R-HSA-8985947] Interleukin-9 signaling

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