Reactome | Interleukin-9 signaling

Interleukin-9 signaling

Stable Identifier

R-HSA-8985947

DOI

10.3180/R-HSA-8985947.4

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Interleukin 9 (IL9) binds interleukin 9 receptor a chain (IL9R) and the interleukin 2 receptor common gamma chain (IL2RG) to initiate IL9 signaling downstream cascade. IL9R colocalize with Interleukin 2 receptor α chain and MHC molecules in lipid rafts of human T lymphoma cells (Nizsalóczki et al. 2014). IL2RG is essential for IL9 dependent growth signal transduction (Kimura et al. 1995). IL9R (glycoprotein of 64 kDa) has saturable and specific binding sites with a Kd of 100 pM (Renauld et al. 1992). The activated IL9R complex recruits tyrosine kinase proteins from the Janus kinase (JAK) family: JAK1 (JAK1) and JAK3 (JAK3) for subsequent activation of the Signal transducer and activator of transcription (STAT) factors STAT1, STAT3 and STAT5. The activated STATs form STAT5 dimers and STAT1:STAT3 heterodimers (Neurath & Finotto 2016, Li & Rostami 2010).

Literature References

PubMed ID	Title	Journal	Year
20020328	IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity Li, H, Rostami, A	J Neuroimmune Pharmacol	2010
25297818	Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells Nizsalóczki, E, Nagy, P, Csomós, I, Waldmann, TA, Goldman, CK, Fazekas, Z, Bodnár, A, Mátyus, L, Vámosi, G, Damjanovich, S	Chemphyschem	2014
26976761	IL-9 signaling as key driver of chronic inflammation in mucosal immunity Finotto, S, Neurath, MF	Cytokine Growth Factor Rev.	2016