Interleukin-9 signaling

Stable Identifier
Homo sapiens
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Interleukin 9 (IL9) binds interleukin 9 receptor a chain (IL9R) and the interleukin 2 receptor common gamma chain (IL2RG) to initiate IL9 signaling downstream cascade. IL9R colocalize with Interleukin 2 receptor α chain and MHC molecules in lipid rafts of human T lymphoma cells (Nizsalóczki et al. 2014). IL2RG is essential for IL9 dependent growth signal transduction (Kimura et al. 1995). IL9R (glycoprotein of 64 kDa) has saturable and specific binding sites with a Kd of 100 pM (Renauld et al. 1992). The activated IL9R complex recruits tyrosine kinase proteins from the Janus kinase (JAK) family: JAK1 (JAK1) and JAK3 (JAK3) for subsequent activation of the Signal transducer and activator of transcription (STAT) factors STAT1, STAT3 and STAT5. The activated STATs form STAT5 dimers and STAT1:STAT3 heterodimers (Neurath & Finotto 2016, Li & Rostami 2010).

Literature References
PubMed ID Title Journal Year
20020328 IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity

Li, H, Rostami, A

J Neuroimmune Pharmacol 2010
25297818 Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells

Nizsalóczki, E, Nagy, P, Csomós, I, Waldmann, TA, Goldman, CK, Fazekas, Z, Bodnár, A, Mátyus, L, Vámosi, G, Damjanovich, S

Chemphyschem 2014
26976761 IL-9 signaling as key driver of chronic inflammation in mucosal immunity

Finotto, S, Neurath, MF

Cytokine Growth Factor Rev. 2016
Event Information
Orthologous Events
Cross References
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