Reactome | STAT1,STAT3 associate with IL27RA:IL12RB2 receptor

Schema > BlackBoxEvent > Entries

STAT1,STAT3 associate with IL27RA:IL12RB2 receptor Show undefined attributes

authored	[InstanceEdit:8952430] Varusai, Thawfeek, 2016-12-15
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8983984] Varusai, Thawfeek, 2017-04-03
dbId	8984021
displayName	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
edited	[InstanceEdit:8952430] Varusai, Thawfeek, 2016-12-15
eventOf	[Pathway:R-HSA-8984722] Interleukin-35 Signalling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8984014] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 - Homo sapiens
input	[Complex:R-HSA-8985392] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-629622] STAT1 [cytosol] [EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984020] IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases [LiteratureReference:8949808] Interleukin-35 induces regulatory B cells that suppress autoimmune disease
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
orthologousEvent	[BlackBoxEvent:R-XTR-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Xenopus tropicalis [BlackBoxEvent:R-SSC-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Sus scrofa [BlackBoxEvent:R-BTA-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Bos taurus [BlackBoxEvent:R-CFA-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Canis familiaris [BlackBoxEvent:R-RNO-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Rattus norvegicus [BlackBoxEvent:R-MMU-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Mus musculus
output	[Complex:R-HSA-8983998] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-8984012] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9011722] Singh, Kailash, 2017-07-05 [InstanceEdit:9015170] Pylayeva-Gupta, Yuliya, 2017-08-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8984021
summation	[Summation:8983976] Interleukin 35 (IL35) binding activates the IL35 receptor co...

Referrals

(hasEvent)	[Pathway:R-HSA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-HSA-8984014] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3