Reactome | STAT1,STAT3 associate with IL27RA:IL12RB2 receptor

STAT1,STAT3 associate with IL27RA:IL12RB2 receptor

Stable Identifier

R-HSA-8984021

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

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STAT1,STAT3 associate with IL27RA:IL12RB2 receptor

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Interleukin 35 (IL35) binding activates the IL35 receptor complex and facilitates JAKs phosphorylation. Subsequently, Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 alpha/beta (STAT3) bind to the receptor complex and are activated by tyrosine phosphorylation (Wang et al. 2014). This is a black box event because the receptor subunit responsible for STAT1 and STAT3 binding to the receptor is unclear.

Literature References

PubMed ID	Title	Journal	Year
24743305	Interleukin-35 induces regulatory B cells that suppress autoimmune disease Wang, RX, Yu, CR, Dambuza, IM, Mahdi, RM, Dolinska, MB, Sergeev, YV, Wingfield, PT, Kim, SH, Egwuagu, CE	Nat. Med.	2014
24572363	IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases Shen, P, Roch, T, Lampropoulou, V, O'Connor, RA, Stervbo, U, Hilgenberg, E, Ries, S, Dang, VD, Jaimes, Y, Daridon, C, Li, R, Jouneau, L, Boudinot, P, Wilantri, S, Sakwa, I, Miyazaki, Y, Leech, MD, McPherson, RC, Wirtz, S, Neurath, M, Hoehlig, K, Meinl, E, Grützkau, A, Grün, JR, Horn, K, Kühl, AA, Dörner, T, Bar-Or, A, Kaufmann, SH, Anderton, SM, Fillatreau, S	Nature	2014