STAT1,STAT3 associate with IL27RA:IL12RB2 receptor

Stable Identifier
R-HSA-8984021
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
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Interleukin 35 (IL35) binding activates the IL35 receptor complex and facilitates JAKs phosphorylation. Subsequently, Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 alpha/beta (STAT3) bind to the receptor complex and are activated by tyrosine phosphorylation (Wang et al. 2014). This is a black box event because the receptor subunit responsible for STAT1 and STAT3 binding to the receptor is unclear.

Literature References
PubMed ID Title Journal Year
24572363 IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Kaufmann, SH, Grützkau, A, Grün, JR, Lampropoulou, V, Li, R, Boudinot, P, Ries, S, Wirtz, S, Bar-Or, A, Shen, P, Meinl, E, Roch, T, McPherson, RC, Anderton, SM, Jaimes, Y, Hoehlig, K, Jouneau, L, Dörner, T, Leech, MD, Horn, K, Kühl, AA, Daridon, C, Sakwa, I, O'Connor, RA, Dang, VD, Stervbo, U, Neurath, M, Wilantri, S, Hilgenberg, E, Miyazaki, Y, Fillatreau, S

Nature 2014
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB

Nat. Med. 2014
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Output
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Authored
Varusai, TM  (2016-12-15)
Reviewed
Pylayeva-Gupta, Y  (2017-08-09)
Singh, K  (2017-07-05)
Created
Varusai, TM  (2017-04-03)
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