19605563 |
The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle
Ford-Speelman, DL,
Roche, JA,
Bowman, AL,
Bloch, RJ
|
Mol. Biol. Cell |
2009 |
16467373 |
A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype
Liu, M,
Horowitz, A
|
Mol. Biol. Cell |
2006 |
7479768 |
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family
Heisterkamp, N,
Xu, X,
Bokoch, GM,
Groffen, J,
Kaartinen, V,
Chuang, TH
|
Proc. Natl. Acad. Sci. U.S.A. |
1995 |
11058585 |
Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules
van Horck, FP,
Ahmadian, MR,
Moolenaar, WH,
Haeusler, LC,
Kranenburg, O
|
J. Biol. Chem. |
2001 |
7721814 |
Direct involvement of the small GTP-binding protein Rho in lbc oncogene function
Olson, MF,
Cerione, RA,
Toksoz, D,
Hall, A,
Zheng, Y
|
J. Biol. Chem. |
1995 |
11884391 |
Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
Zeng, L,
Sachdev, P,
Wang, LH
|
J. Biol. Chem. |
2002 |
14512443 |
G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production
Pan, H,
Profirovic, J,
Voyno-Yasenetskaya, T,
Vaiskunaite, R,
Niu, J
|
Circ. Res. |
2003 |
19635168 |
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10
Aoki, T,
Kataoka, T,
Satoh, T,
Ueda, S
|
BMC Cell Biol. |
2009 |
9822605 |
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2
Bustelo, XR,
Schuebel, KE,
Rosa, JL,
Movilla, N
|
EMBO J. |
1998 |
10523665 |
Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation
Kay, R,
Lambert, QT,
Rossman, KL,
Glaven, JA,
Mahon, GM,
Campbell, SL,
Abe, K,
Trzaskos, JM,
Whitehead, IP,
Der, CJ
|
Mol. Cell. Biol. |
1999 |
11606631 |
Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology
Eipper, BA,
Johnson, RC,
Mains, RE,
Penzes, P,
Kambampati, V
|
J Neurosci |
2001 |
7753201 |
A role for Rac in Tiam1-induced membrane ruffling and invasion
van der Kammen, RA,
Michiels, F,
Stam, JC,
Collard, JG,
Habets, GG
|
Nature |
1995 |
17562871 |
Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1
Katan, M,
Jones, NP
|
Mol. Cell. Biol. |
2007 |
28196833 |
Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering
Zeghouf, M,
Ladid, I,
Veyron, S,
Ferrandez, Y,
Cherfils, J,
Peurois, F,
Peyroche, G,
Benabdi, S
|
Biochem. J. |
2017 |
8643598 |
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains
Serra-Pagès, C,
Debant, A,
Park, SH,
O'Brien, S,
Seipel, K,
Streuli, M,
Tang, M
|
Proc Natl Acad Sci U S A |
1996 |
9659915 |
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
Manser, E,
Loo, TH,
Leung, T,
Lim, L,
Koh, CG,
Zhao, ZS,
Tan, I,
Chen, XQ,
Tan, L
|
Mol Cell |
1998 |
11680691 |
Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cells
Kato, Y,
Kuruta, Y,
Kikuchi, A,
Koyano, Y,
Fujii, K,
Kawamoto, T,
Shen, M,
Tsutsumi, S,
Fujimoto, K,
Noshiro, M
|
Osteoarthr. Cartil. |
2001 |
12221096 |
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
Der, CJ,
Burridge, K,
Ellerbroek, SM,
Arthur, WT,
Wennerberg, K
|
J. Biol. Chem. |
2002 |
11704860 |
The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3
Blangy, A,
De Toledo, M,
Schmidt, S,
Coulon, V,
Fort, P
|
Oncogene |
2001 |
9670022 |
Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1
Alberts, AS,
Treisman, R
|
EMBO J. |
1998 |
11373293 |
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA
Booden, MA,
Lambert, QT,
Caligiuri, MA,
Sondek, J,
Reuther, GW,
Wennerberg, K,
Marcucci, G,
Becknell, B,
Der, CJ
|
J. Biol. Chem. |
2001 |
27986909 |
SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines
Scita, G,
Laudanna, C,
Mirenda, M,
Montresor, A,
Toffali, L
|
J. Immunol. |
2017 |
23572525 |
Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases
Manor, D,
Gupta, M,
Sharma, G,
Brathwaite, S,
Wang, H,
Muakkassa, N,
Chung, S,
Kamynina, E,
Morley, S
|
J. Biol. Chem. |
2013 |
26887924 |
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
White, G,
Vennin, C,
Woroniuk, A,
Timpson, P,
Malliri, A,
Carpy, A,
Marei, H,
Macek, B
|
Nat Commun |
2016 |
17702745 |
Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation
Jing, X,
Yan, X,
Sawada, T,
Yokote, H,
Sakaguchi, K,
Zhang, Y
|
J. Biol. Chem. |
2007 |
15485661 |
WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney
Kihara, R,
Sone, H,
Suzuki, H,
Toyoshima, H,
Watanabe, K,
Shimano, H,
Yamada, N,
Yokoo, T,
Tada-Iida, K,
Miura, M,
Wang, Y
|
Biochem. Biophys. Res. Commun. |
2004 |
16896804 |
Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture
Winkler, S,
Mohl, M,
Lutz, S,
Wieland, T
|
Naunyn Schmiedebergs Arch. Pharmacol. |
2006 |
15107133 |
Scambio, a novel guanine nucleotide exchange factor for Rho
Groffen, J,
Heisterkamp, N,
Senadheera, D,
Haataja, L,
Curtis, C,
Hemmeryckx, B
|
Mol. Cancer |
2004 |
10523675 |
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
Bustelo, XR,
Movilla, N
|
Mol. Cell. Biol. |
1999 |
27145964 |
ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells
Oie, S,
Fukushima, H,
Yasumoto, M,
Mizuarai, S,
Ogasawara, S,
Ishida, Y,
Itadani, H,
Yano, H,
Horiuchi, H,
Yasunaga, M,
Naito, Y,
Nakayama, M,
Sakamoto, E,
Kitasato, Y,
Okabe, Y,
Akiba, J
|
Mol. Cancer |
2016 |
22911862 |
Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4
Der, CJ,
Rossman, KL,
Mitin, N
|
PLoS ONE |
2012 |
16112081 |
GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor
Winkler, S,
Mohl, M,
Lutz, S,
Wieland, T
|
Biochem. Biophys. Res. Commun. |
2005 |
17942708 |
Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans
Jorgensen, EM,
Ailion, M,
Miller, KG,
Tesmer, JJ,
Charlie, NK,
Coco, C,
Lutz, S,
Vettel, C,
Wieland, T,
Williams, SL
|
Genes Dev |
2007 |
31871319 |
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms
Tran, V,
Gingras, AC,
Elkholi, IE,
Robert, A,
Boulais, J,
Faubert, D,
Dubé, N,
Hipfner, DR,
Cote, JF,
Lin, ZY,
Bagci, H,
Sriskandarajah, N,
Thibault, MP
|
Nat. Cell Biol. |
2020 |
10526156 |
Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member
Schablowski, H,
Rümenapp, U,
Psoma, A,
Schwörer, G,
Jakobs, KH,
Blomquist, A
|
FEBS Lett. |
1999 |
15850391 |
Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors
Campbell, SL,
Thapar, R,
Heo, J
|
Biochemistry |
2005 |
15601624 |
TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner
Miki, T,
Chang, SW,
Xie, X,
Tatsumoto, T,
Chan, AM
|
Cell. Signal. |
2005 |
23255595 |
Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins
Ahmadian, MR,
Jaiswal, M,
Dvorsky, R
|
J. Biol. Chem. |
2013 |
22673745 |
Divergence of Rho residue 43 impacts GEF activity
Quinn, CV,
Goetzinger, C,
Farley, J,
Sloan, CM,
Ellerbroek, SM,
Peters, JP,
Wernli, M,
DeMali, KA
|
Small GTPases |
2012 |
11912491 |
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton
Bokoch, GM,
Krendel, M,
Zenke, FT
|
Nat. Cell Biol. |
2002 |
32203420 |
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions
Pawson, T,
Freitag, K,
Zhang, S,
Bakal, C,
Popp, O,
Petsalaki, E,
Giudice, G,
Mertins, P,
Bagshaw, RD,
Larsen, B,
Rrustemi, T,
Brandenburg, L,
Nguyen, V,
Roth, FP,
Sanchez-Castro, M,
Barth, C,
Eccles, RL,
Czajkowski, MT,
Rademacher, J,
Colwill, K,
Pascual-Vargas, P,
Wortmann, C,
Pertz, O,
Tucholska, M,
Alp, KM,
Rocks, O,
Trnka, P,
Mbamalu, G,
van Unen, J,
Spatt, L,
Müller, PM,
Heinrich, LE,
Welke, RW,
Gingras, AC
|
Nat Cell Biol |
2020 |
19713215 |
Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5
Lehmann, D,
Gan, X,
Wang, P,
Wang, Z,
Li, L,
Smrcka, AV,
Iwasaki, A,
Wu, D,
Cohn, L,
Kumamoto, Y
|
J. Biol. Chem. |
2009 |
12071859 |
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain
Rümenapp, U,
Wittinghofer, B,
Wieland, T,
Jakobs, KH,
Freichel-Blomquist, A
|
Biochem. J. |
2002 |
8810315 |
Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
Bollag, G,
Qiu, RG,
elMasry, N,
McCabe, P,
Sharma, S,
Polakis, P,
Hart, MJ
|
J Biol Chem |
1996 |
10579713 |
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
Blumenthal, R,
Okamoto, I,
Tatsumoto, T,
Xie, X,
Miki, T
|
J. Cell Biol. |
1999 |
11085924 |
Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor
Schablowski, H,
Rümenapp, U,
Psoma, A,
Schwörer, G,
Jakobs, KH,
Lehnen, M,
Blomquist, A
|
Biochem. J. |
2000 |
15023524 |
DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA
Jones, P,
Sablitzky, F,
McKinlay, KJ,
Mavrakis, KJ
|
Exp. Cell Res. |
2004 |
21454492 |
Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)
Cirstea, IC,
Ahmadian, MR,
Uhlenbrock, K,
Jaiswal, M,
Dvorsky, R,
Gremer, L,
Haeusler, LC
|
J. Biol. Chem. |
2011 |