Reactome | HDL remodeling

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HDL remodeling Show undefined attributes

authored	[InstanceEdit:349660] D'Eustachio, P, 2008-05-12 17:46:52
created	[InstanceEdit:8964059] D'Eustachio, Peter, 2017-02-14
crossReference	[DatabaseIdentifier:12819519] BioModels Database:BIOMD0000000434
dbId	8964058
deleted	[Deleted:8964447] Deletion of instance: 194223
displayName	HDL remodeling
edited	[InstanceEdit:350212] D'Eustachio, P, 2008-05-14 17:46:32
eventOf	[Pathway:R-HSA-8963899] Plasma lipoprotein remodeling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:357924] high-density lipoprotein particle remodeling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-266082] ABCG1-mediated transport of intracellular cholesterol to the cell surface - Homo sapiens [Reaction:R-HSA-266089] Discoidal HDL binds membrane-associated free cholesterol - Homo sapiens [Reaction:R-HSA-264678] LCAT + discoidal HDL <=> LCAT:discoidal HDL complex - Homo sapiens [Reaction:R-HSA-264689] LCAT:discoidal HDL complex <=> LCAT + discoidal HDL - Homo sapiens [Reaction:R-HSA-266303] Spherical HDL binds C and E apolipoproteins - Homo sapiens [Reaction:R-HSA-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids - Homo sapiens [Reaction:R-HSA-264695] cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) - Homo sapiens [Reaction:R-HSA-264679] Serum albumin binds 2-lysophosphatidylcholine - Homo sapiens [Reaction:R-HSA-266315] LCAT + spherical HDL <=> LCAT:spherical HDL complex - Homo sapiens [Reaction:R-HSA-266310] LCAT:spherical HDL complex <=> LCAT + spherical HDL - Homo sapiens [Reaction:R-HSA-266328] CETP-mediated lipid exchange: spherical HDL gains triacylglycerol - Homo sapiens [Reaction:R-HSA-349404] CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex - Homo sapiens [Reaction:R-HSA-8980228] LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:349408] Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action [LiteratureReference:349665] HDL, ABC Transporters, and Cholesterol Efflux: Implications for the Treatment of Atherosclerosis [LiteratureReference:266086] ABCG1 redistributes cellular cholesterol to domains removable by high density lipoproteins but not by lipid-depleted lipoproteins
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	HDL remodeling
orthologousEvent	[Pathway:R-PFA-8964058] HDL remodeling - Plasmodium falciparum [Pathway:R-SCE-8964058] HDL remodeling - Saccharomyces cerevisiae [Pathway:R-DDI-8964058] HDL remodeling - Dictyostelium discoideum [Pathway:R-CEL-8964058] HDL remodeling - Caenorhabditis elegans [Pathway:R-DME-8964058] HDL remodeling - Drosophila melanogaster [Pathway:R-GGA-8964058] HDL remodeling - Gallus gallus [Pathway:R-XTR-8964058] HDL remodeling - Xenopus tropicalis [Pathway:R-DRE-8964058] HDL remodeling - Danio rerio [Pathway:R-SSC-8964058] HDL remodeling - Sus scrofa [Pathway:R-BTA-8964058] HDL remodeling - Bos taurus [Pathway:R-CFA-8964058] HDL remodeling - Canis familiaris [Pathway:R-RNO-8964058] HDL remodeling - Rattus norvegicus [Pathway:R-MMU-8964058] HDL remodeling - Mus musculus
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:353689] Jassal, Bijay, 2008-06-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8964058
summation	[Summation:8964030] HDL (high-density lipoprotein) particles play a central role...
updateTrackers	[UpdateTracker:9775901] Update Tracker - [Pathway:8964058] HDL remodeling - v78:[updateContainedRLE] [UpdateTracker:9775093] Update Tracker - [Pathway:8964058] HDL remodeling - v80:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775901] Update Tracker - [Pathway:8964058] HDL remodeling - v78:[updateContainedRLE] [UpdateTracker:9775093] Update Tracker - [Pathway:8964058] HDL remodeling - v80:[updateContainedRLE]
(replacementInstances)	[Deleted:8964447] Deletion of instance: 194223
(hasEvent)	[Pathway:R-HSA-8963899] Plasma lipoprotein remodeling

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