Reactome | HDL remodeling

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HDL remodeling Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099921
displayName	HDL remodeling
eventOf	[Pathway:R-MMU-8963899] Plasma lipoprotein remodeling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:357924] high-density lipoprotein particle remodeling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-266082] ABCG1-mediated transport of intracellular cholesterol to the cell surface - Mus musculus [Reaction:R-MMU-266089] Discoidal HDL binds membrane-associated free cholesterol - Mus musculus [Reaction:R-MMU-264678] LCAT + discoidal HDL <=> LCAT:discoidal HDL complex - Mus musculus [Reaction:R-MMU-264689] LCAT:discoidal HDL complex <=> LCAT + discoidal HDL - Mus musculus [Reaction:R-MMU-266303] Spherical HDL binds C and E apolipoproteins - Mus musculus [Reaction:R-MMU-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids - Mus musculus [Reaction:R-MMU-264695] cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) - Mus musculus [Reaction:R-MMU-264679] Serum albumin binds 2-lysophosphatidylcholine - Mus musculus [Reaction:R-MMU-266315] LCAT + spherical HDL <=> LCAT:spherical HDL complex - Mus musculus [Reaction:R-MMU-266310] LCAT:spherical HDL complex <=> LCAT + spherical HDL - Mus musculus [Reaction:R-MMU-8980228] LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA - Mus musculus
inferredFrom	[Pathway:R-HSA-8964058] HDL remodeling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HDL remodeling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-8964058
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963899] Plasma lipoprotein remodeling
(inferredTo)	[Pathway:R-HSA-8964058] HDL remodeling

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