Reactome | Assembly of active LPL and LIPC lipase complexes

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Assembly of active LPL and LIPC lipase complexes Show undefined attributes

authored	[InstanceEdit:8856523] Jassal, Bijay, 2016-02-10 [InstanceEdit:6784714] Sanchis, Alba, 2015-05-12
created	[InstanceEdit:8963894] D'Eustachio, Peter, 2017-02-13
dbId	8963889
displayName	Assembly of active LPL and LIPC lipase complexes
edited	[InstanceEdit:8856523] Jassal, Bijay, 2016-02-10
eventOf	[Pathway:R-HSA-8963899] Plasma lipoprotein remodeling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:357877] plasma lipoprotein particle remodeling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6784861] HSPG binds LPL dimer - Homo sapiens [Reaction:R-HSA-8857928] GPIHBP1 binds HSPG:LPL dimer - Homo sapiens [Reaction:R-HSA-8856525] ANGPTL8 binds ANGPTL3 - Homo sapiens [Reaction:R-HSA-6784628] PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Homo sapiens [Reaction:R-HSA-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Homo sapiens [Reaction:R-HSA-6784620] MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) - Homo sapiens [BlackBoxEvent:R-HSA-6784648] CREB3L3 (1-?) translocates from cytosol to nucleoplasm - Homo sapiens [BlackBoxEvent:R-HSA-6784622] APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins - Homo sapiens [Reaction:R-HSA-6785181] LMF1,2 bind LIPC dimer - Homo sapiens [BlackBoxEvent:R-HSA-6785178] LMF1,2 transport LIPC dimer from ER lumen to extracellular region - Homo sapiens [Reaction:R-HSA-6785213] LIPC dimer binds heparin - Homo sapiens [Reaction:R-HSA-5694109] LIPC dimer hydrolyses TAG to DAG and FA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6785184] Purification, cellular levels, and functional domains of lipase maturation factor 1 [LiteratureReference:8867483] Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells [LiteratureReference:6784717] The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism [LiteratureReference:6784650] Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue [LiteratureReference:8857965] GPIHBP1, an endothelial cell transporter for lipoprotein lipase [LiteratureReference:9861379] Characterization of a peptide containing the major heparin binding domain of human hepatic lipase
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Assembly of active LPL and LIPC lipase complexes
orthologousEvent	[Pathway:R-DME-8963889] Assembly of active LPL and LIPC lipase complexes - Drosophila melanogaster [Pathway:R-GGA-8963889] Assembly of active LPL and LIPC lipase complexes - Gallus gallus [Pathway:R-XTR-8963889] Assembly of active LPL and LIPC lipase complexes - Xenopus tropicalis [Pathway:R-DRE-8963889] Assembly of active LPL and LIPC lipase complexes - Danio rerio [Pathway:R-SSC-8963889] Assembly of active LPL and LIPC lipase complexes - Sus scrofa [Pathway:R-BTA-8963889] Assembly of active LPL and LIPC lipase complexes - Bos taurus [Pathway:R-CFA-8963889] Assembly of active LPL and LIPC lipase complexes - Canis familiaris [Pathway:R-RNO-8963889] Assembly of active LPL and LIPC lipase complexes - Rattus norvegicus [Pathway:R-MMU-8963889] Assembly of active LPL and LIPC lipase complexes - Mus musculus
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8868240] D'Eustachio, Peter, 2016-04-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8963889
summation	[Summation:8963895] Lipoprotein lipase (LPL) and hepatic triacylglycerol lipase ...
updateTrackers	[UpdateTracker:9864325] Update Tracker - [Pathway:8963889] Assembly of active LPL and LIPC lipase complexes - v88:[add_removeLiteratureReference, modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9864325] Update Tracker - [Pathway:8963889] Assembly of active LPL and LIPC lipase complexes - v88:[add_removeLiteratureReference, modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-8963899] Plasma lipoprotein remodeling

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