Reactome | PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer

Schema > Reaction > Entries

PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer Show undefined attributes

authored	[InstanceEdit:6784714] Sanchis, Alba, 2015-05-12
catalystActivity	[CatalystActivity:6784715] endopeptidase activity of PCSK5 [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643558] endopeptidase activity of PCSK5 [extracellular region] Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:6784679] Sanchis, Alba, 2015-06-22
dbId	6784676
displayName	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
edited	[InstanceEdit:6797313] Jassal, Bijay, 2015-09-08
eventOf	[Pathway:R-HSA-8963889] Assembly of active LPL and LIPC lipase complexes - Homo sapiens
input	[Complex:R-HSA-8857969] GPIHBP1:HSPG:LPL dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6784650] Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue [LiteratureReference:6797319] Cleavage of endometrial ?-integrins into their functional forms is mediated by proprotein convertase 5/6
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
orthologousEvent	[Reaction:R-DME-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Drosophila melanogaster [Reaction:R-GGA-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Gallus gallus [Reaction:R-SSC-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Sus scrofa [Reaction:R-BTA-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Bos taurus [Reaction:R-CFA-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Canis familiaris [Reaction:R-RNO-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Rattus norvegicus [Reaction:R-MMU-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5216067] GPIHBP1 [plasma membrane] [SimpleEntity:R-ALL-1678620] HSPG [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-174605] LPL [extracellular region]
regulatedBy	[PositiveRegulation:R-HSA-6784872] Positive regulation by 'ANGPTL4 [extracellular region]'
regulationReference	[RegulationReference:9642708] Positive regulation by 'ANGPTL4 [extracellular region]' Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8868240] D'Eustachio, Peter, 2016-04-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6784676
summation	[Summation:6784653] LPL enzyme is catalytically active as a dimer composed of tw...

Referrals

(hasEvent)

[Pathway:R-HSA-8963889] Assembly of active LPL and LIPC lipase complexes