Reactome | Assembly of active LPL and LIPC lipase complexes

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Assembly of active LPL and LIPC lipase complexes Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101331
displayName	Assembly of active LPL and LIPC lipase complexes
eventOf	[Pathway:R-MMU-8963899] Plasma lipoprotein remodeling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:357877] plasma lipoprotein particle remodeling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-6784861] HSPG binds LPL dimer - Mus musculus [Reaction:R-MMU-8857928] GPIHBP1 binds HSPG:LPL dimer - Mus musculus [Reaction:R-MMU-8856525] ANGPTL8 binds ANGPTL3 - Mus musculus [Reaction:R-MMU-6784628] PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Mus musculus [Reaction:R-MMU-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Mus musculus [Reaction:R-MMU-6785181] LMF1,2 bind LIPC dimer - Mus musculus [BlackBoxEvent:R-MMU-6785178] LMF1,2 transport LIPC dimer from ER lumen to extracellular region - Mus musculus [Reaction:R-MMU-6785213] LIPC dimer binds heparin - Mus musculus [Reaction:R-MMU-5694109] LIPC dimer hydrolyses TAG to DAG and FA - Mus musculus
inferredFrom	[Pathway:R-HSA-8963889] Assembly of active LPL and LIPC lipase complexes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Assembly of active LPL and LIPC lipase complexes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-8963889
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963899] Plasma lipoprotein remodeling
(inferredTo)	[Pathway:R-HSA-8963889] Assembly of active LPL and LIPC lipase complexes

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