Reactome | LC3 binds the autophagosome membrane Atg5-Atg12 complex

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LC3 binds the autophagosome membrane Atg5-Atg12 complex Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
category	binding
compartment	[Compartment:21994] phagocytic vesicle
created	[InstanceEdit:8959569] Gillespie, Marc E, 2017-01-26
dbId	8959571
displayName	LC3 binds the autophagosome membrane Atg5-Atg12 complex
edited	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
eventOf	[Pathway:R-HSA-8934903] Receptor Mediated Mitophagy - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9698265] Enhanced autophagosome formation - Homo sapiens [BlackBoxEvent:R-HSA-9687435] Enhanced autophagosome formation - Homo sapiens [BlackBoxEvent:R-HSA-5682388] Autophagosome maturation - Homo sapiens
input	[Complex:R-HSA-5205638] ATG5:ATG12 [phagocytic vesicle membrane] [Complex:R-HSA-8959568] p-S17-FUNDC1:LC3 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5205644] Autophagosome formation and molecular mechanism of autophagy
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	LC3 binds the autophagosome membrane Atg5-Atg12 complex
orthologousEvent	[Reaction:R-SCE-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Saccharomyces cerevisiae [Reaction:R-SPO-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Schizosaccharomyces pombe [Reaction:R-CEL-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Caenorhabditis elegans [Reaction:R-GGA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Gallus gallus [Reaction:R-DRE-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Danio rerio [Reaction:R-SSC-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Sus scrofa [Reaction:R-BTA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Bos taurus [Reaction:R-RNO-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Rattus norvegicus [Reaction:R-MMU-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Mus musculus
output	[Complex:R-HSA-8959570] p-S17-FUNDC1:LC3:ATG5:ATG12 [cytosol]
precedingEvent	[Reaction:R-HSA-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959558] Feng, Du, 2017-01-26
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8959571
summation	[Summation:5205627] The mitochondrion is engulfed after elongation of the isolat...
updateTrackers	[UpdateTracker:9864010] Update Tracker - [Reaction:8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - v88:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864010] Update Tracker - [Reaction:8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - v88:[modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9698265] Enhanced autophagosome formation [BlackBoxEvent:R-HSA-9687435] Enhanced autophagosome formation [BlackBoxEvent:R-HSA-5682388] Autophagosome maturation
(hasEvent)	[Pathway:R-HSA-8934903] Receptor Mediated Mitophagy