Reactome | LC3 binds the autophagosome membrane Atg5-Atg12 complex

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LC3 binds the autophagosome membrane Atg5-Atg12 complex Show undefined attributes

category	binding
compartment	[Compartment:21994] phagocytic vesicle
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084247
displayName	LC3 binds the autophagosome membrane Atg5-Atg12 complex
eventOf	[Pathway:R-MMU-8934903] Receptor Mediated Mitophagy - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-5682388] Autophagosome maturation - Mus musculus
inferredFrom	[Reaction:R-HSA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Homo sapiens
input	[Complex:R-MMU-5205638] ATG5:ATG12 [phagocytic vesicle membrane] [Complex:R-MMU-8959568] p-S17-FUNDC1:LC3 [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	LC3 binds the autophagosome membrane Atg5-Atg12 complex
output	[Complex:R-MMU-8959570] p-S17-FUNDC1:LC3:ATG5:ATG12 [cytosol]
precedingEvent	[Reaction:R-MMU-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8959571
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[BlackBoxEvent:R-MMU-5682388] Autophagosome maturation
(hasEvent)	[Pathway:R-MMU-8934903] Receptor Mediated Mitophagy
(inferredTo)	[Reaction:R-HSA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex

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