LC3 binds the autophagosome membrane Atg5-Atg12 complex

Stable Identifier
R-HSA-8959571
Type
Reaction [binding]
Species
Homo sapiens
Compartment
phagocytic vesicle
ReviewStatus
5/5
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LC3 binds the autophagosome membrane Atg5-Atg12 complex
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The mitochondria are engulfed after elongation of the isolation membrane. Once the autophagosome is formed, its outer membrane fuses with lysosomes to form the autolysosome. The lysosomal hydrolases (cathepsins and lipases) ultimately degrade the damaged mitochondria and its associated proteins.

Literature References
PubMed ID Title Journal Year
20712405 Autophagosome formation and molecular mechanism of autophagy

Tanida, I

Antioxid. Redox Signal. 2011
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Orthologous Events
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LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Saccharomyces cerevisiae)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Schizosaccharomyces pombe)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)
Authored
Gillespie, ME  (2013-11-21)
Reviewed
Feng, D  (2017-01-26)
Created
Gillespie, ME  (2017-01-27)
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