LC3 binds the autophagosome membrane Atg5-Atg12 complex

Stable Identifier
R-HSA-8959571
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The mitochondria are engulfed after elongation of the isolation membrane. Once the autophagosome is formed, its outer membrane fuses with lysosomes to form the autolysosome. The lysosomal hydrolases (cathepsins and lipases) ultimately degrade the damaged mitochondria and its associated proteins.

Literature References
PubMed ID Title Journal Year
20712405 Autophagosome formation and molecular mechanism of autophagy

Tanida, I

Antioxid. Redox Signal. 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created