Reactome | Receptor Mediated Mitophagy

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Receptor Mediated Mitophagy Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8934928] Gillespie, Marc E, 2016-08-12
dbId	8934903
displayName	Receptor Mediated Mitophagy
doi	10.3180/R-HSA-8934903.1
edited	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
eventOf	[Pathway:R-HSA-5205647] Mitophagy - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20607] macroautophagy
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8948039] FUNDC1 is phosphorylated by CK2 - Homo sapiens [Reaction:R-HSA-8948143] p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 - Homo sapiens [Reaction:R-HSA-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Homo sapiens [Reaction:R-HSA-8948136] ULK1 Translocates to the mitochondria - Homo sapiens [Reaction:R-HSA-8948146] FUNDC1 is phosphorylated by ULK1 at Ser17 - Homo sapiens [Reaction:R-HSA-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3 - Homo sapiens [Reaction:R-HSA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-09-30
literatureReference	[LiteratureReference:8934909] Essential role for Nix in autophagic maturation of erythroid cells [LiteratureReference:8934896] Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells [LiteratureReference:8934920] Molecular signaling toward mitophagy and its physiological significance [LiteratureReference:8934930] NIX induces mitochondrial autophagy in reticulocytes [LiteratureReference:8934929] Nix is a selective autophagy receptor for mitochondrial clearance [LiteratureReference:8934912] ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy [LiteratureReference:8934921] Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Receptor Mediated Mitophagy
orthologousEvent	[Pathway:R-SCE-8934903] Receptor Mediated Mitophagy - Saccharomyces cerevisiae [Pathway:R-SPO-8934903] Receptor Mediated Mitophagy - Schizosaccharomyces pombe [Pathway:R-DDI-8934903] Receptor Mediated Mitophagy - Dictyostelium discoideum [Pathway:R-CEL-8934903] Receptor Mediated Mitophagy - Caenorhabditis elegans [Pathway:R-DME-8934903] Receptor Mediated Mitophagy - Drosophila melanogaster [Pathway:R-GGA-8934903] Receptor Mediated Mitophagy - Gallus gallus [Pathway:R-XTR-8934903] Receptor Mediated Mitophagy - Xenopus tropicalis [Pathway:R-DRE-8934903] Receptor Mediated Mitophagy - Danio rerio [Pathway:R-SSC-8934903] Receptor Mediated Mitophagy - Sus scrofa [Pathway:R-BTA-8934903] Receptor Mediated Mitophagy - Bos taurus [Pathway:R-CFA-8934903] Receptor Mediated Mitophagy - Canis familiaris [Pathway:R-RNO-8934903] Receptor Mediated Mitophagy - Rattus norvegicus [Pathway:R-MMU-8934903] Receptor Mediated Mitophagy - Mus musculus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959558] Feng, Du, 2017-01-26
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8934903
summation	[Summation:8934917] Mitochondrial autophagy in mammalian cells was first observe...
updateTrackers	[UpdateTracker:9863993] Update Tracker - [Pathway:8934903] Receptor Mediated Mitophagy - v88:[updateContainedRLE] [UpdateTracker:9778993] Update Tracker - [Pathway:8934903] Receptor Mediated Mitophagy - v66:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9863993] Update Tracker - [Pathway:8934903] Receptor Mediated Mitophagy - v88:[updateContainedRLE] [UpdateTracker:9778993] Update Tracker - [Pathway:8934903] Receptor Mediated Mitophagy - v66:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5205647] Mitophagy

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