Reactome | 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

Stable Identifier

R-HSA-8956184

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NUB1 mediates the 26S proteasome-dependent degradation of NEDD8, UBN (also known as FAT10) and their protein conjugates (Kamitani et al, 2001; Tanji et al, 2005;Schmidtke et al, 2006; reviewed in Tanaka et al, 2012; Schmidtke et al, 2014). Unlike the case for ubiquitin, the NEDD8 moiety also seems to be subject to degradation along with its conjugated proteins.

Literature References

PubMed ID	Title	Journal	Year
11585840	Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 Kito, K, Fukuda-Kamitani, T, Yeh, ET, Kamitani, T	J. Biol. Chem.	2001
16171779	Interaction of NUB1 with the proteasome subunit S5a Tanaka, T, Tanji, K, Kamitani, T	Biochem. Biophys. Res. Commun.	2005
16707496	The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10 Groettrup, M, Hipp, MS, Schmidtke, G, Kalveram, B, Lukasiak, S, Bochtler, P, Weber, E	J. Biol. Chem.	2006
22306028	Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy Tanaka, T, Nakatani, T, Kamitani, T	Mol Oncol	2012
23333871	FAT10ylation as a signal for proteasomal degradation Aichem, A, Groettrup, M, Schmidtke, G	Biochim. Biophys. Acta	2014