26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

Stable Identifier
Reaction [omitted]
Homo sapiens
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NUB1 mediates the 26S proteasome-dependent degradation of NEDD8, UBN (also known as FAT10) and their protein conjugates (Kamitani et al, 2001; Tanji et al, 2005;Schmidtke et al, 2006; reviewed in Tanaka et al, 2012; Schmidtke et al, 2014). Unlike the case for ubiquitin, the NEDD8 moiety also seems to be subject to degradation along with its conjugated proteins.
Literature References
PubMed ID Title Journal Year
11585840 Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1

Kito, K, Fukuda-Kamitani, T, Yeh, ET, Kamitani, T

J. Biol. Chem. 2001
16171779 Interaction of NUB1 with the proteasome subunit S5a

Tanaka, T, Tanji, K, Kamitani, T

Biochem. Biophys. Res. Commun. 2005
16707496 The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

Groettrup, M, Hipp, MS, Schmidtke, G, Kalveram, B, Lukasiak, S, Bochtler, P, Weber, E

J. Biol. Chem. 2006
22306028 Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy

Tanaka, T, Nakatani, T, Kamitani, T

Mol Oncol 2012
23333871 FAT10ylation as a signal for proteasomal degradation

Aichem, A, Groettrup, M, Schmidtke, G

Biochim. Biophys. Acta 2014
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