Reactome | COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex

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COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8956043] deNEDDylase activity of COP9 signalosome [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8956044] Rothfels, Karen, 2017-01-13
dbId	8956045
displayName	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input	[Complex:R-HSA-8952585] NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8956000] Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels [LiteratureReference:8956009] The COP9 signalosome regulates Skp2 levels and proliferation of human cells [LiteratureReference:8955981] Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability [LiteratureReference:8953197] F-box-directed CRL complex assembly and regulation by the CSN and CAND1 [LiteratureReference:8955995] Structural basis for a reciprocal regulation between SCF and CSN [LiteratureReference:8955463] CSN- and CAND1-dependent remodelling of the budding yeast SCF complex [LiteratureReference:8955437] CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire [LiteratureReference:8953261] The COP9 signalosome: more than a protease [LiteratureReference:8955979] Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
orthologousEvent	[Reaction:R-DDI-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Dictyostelium discoideum [Reaction:R-CEL-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Caenorhabditis elegans [Reaction:R-DME-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Drosophila melanogaster [Reaction:R-GGA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Gallus gallus [Reaction:R-XTR-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Xenopus tropicalis [Reaction:R-DRE-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-SSC-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Sus scrofa [Reaction:R-BTA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-CFA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Canis familiaris [Reaction:R-RNO-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Rattus norvegicus [Reaction:R-MMU-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Mus musculus
output	[Complex:R-HSA-8955960] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8955926] NEDD8 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8956045
summation	[Summation:8979125] The COP9 signalosome (also known as CSN) is a highly conserv...

Referrals

(hasEvent)

[Pathway:R-HSA-8951664] Neddylation

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