Reactome | COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex

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COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex Show undefined attributes

catalystActivity	[CatalystActivity:10314842] deNEDDylase activity of COP9 signalosome [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10314844
displayName	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
eventOf	[Pathway:R-CFA-8951664] Neddylation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-CFA-8952585] NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
output	[Complex:R-CFA-8955960] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-8955926] NEDD8 [nucleoplasm]
precedingEvent	[Reaction:R-CFA-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8956045
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8951664] Neddylation
(inferredTo)	[Reaction:R-HSA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex

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