Reactome | AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex

Schema > Reaction > Entries

AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8952637] NEDD8 transferase activity of NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8952636] Rothfels, Karen, 2016-12-15
dbId	8952638
displayName	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-HSA-8952580] NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5691194] Covalent modification of all members of human cullin family proteins by NEDD8 [LiteratureReference:8952201] Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation [LiteratureReference:8955148] Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B [LiteratureReference:8955171] The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications [LiteratureReference:8953189] Cullin E3 ligases and their rewiring by viral factors
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex
orthologousEvent	[Reaction:R-DDI-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Dictyostelium discoideum [Reaction:R-DME-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Drosophila melanogaster [Reaction:R-DRE-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-SSC-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Sus scrofa [Reaction:R-BTA-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-CFA-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Canis familiaris [Reaction:R-RNO-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Rattus norvegicus [Reaction:R-MMU-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8952502] AcM-UBE2M [nucleoplasm] [Complex:R-HSA-8952585] NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952638
summation	[Summation:8955250] UBE2M transfers NEDD8 to lysine 705 of CUL4A and lysine 859 ...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex