Reactome | COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

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COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes Show undefined attributes

catalystActivity	[CatalystActivity:10314835] deNEDDylase activity of COP9 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10314837
displayName	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
eventOf	[Pathway:R-CFA-8951664] Neddylation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Canis familiaris
inferredFrom	[Reaction:R-HSA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Homo sapiens
input	[DefinedSet:R-CFA-8956021] NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
output	[DefinedSet:R-CFA-8956019] CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] [EntityWithAccessionedSequence:R-CFA-416969] NEDD8 [cytosol]
precedingEvent	[Reaction:R-CFA-8952044] AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex - Canis familiaris [Reaction:R-CFA-8952618] AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex - Canis familiaris [Reaction:R-CFA-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8956040
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8951664] Neddylation
(precedingEvent)	[Reaction:R-CFA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome
(inferredTo)	[Reaction:R-HSA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

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