Reactome | COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex

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COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8955286] Rothfels, Karen, 2017-01-10
dbId	8955285
displayName	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-HSA-8955650] COMMDs:CCDC22 [nucleoplasm] [Complex:R-HSA-8955244] CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8955456] COMMD proteins, a novel family of structural and functional homologs of MURR1 [LiteratureReference:8955457] COMMD proteins: COMMing to the scene [LiteratureReference:8955461] COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase [LiteratureReference:8955459] COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding [LiteratureReference:8955442] CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling [LiteratureReference:8955690] COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
orthologousEvent	[Reaction:R-DDI-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Dictyostelium discoideum [Reaction:R-XTR-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Xenopus tropicalis [Reaction:R-DRE-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-SSC-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Sus scrofa [Reaction:R-BTA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-CFA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Canis familiaris [Reaction:R-RNO-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Rattus norvegicus [Reaction:R-MMU-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8955089] CAND1 [nucleoplasm] [Complex:R-HSA-8955268] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8955285
summation	[Summation:8955478] COMMD1 is a member of a family of 10 copper metabolism MURR1...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex [NegativePrecedingEvent:9767174] Futile Cycle: COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex