Reactome | CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus

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CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8955243] Rothfels, Karen, 2017-01-10
dbId	8955245
displayName	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8955089] CAND1 [nucleoplasm] [Complex:R-HSA-976149] RBX1:CUL4:DDB1:DCAFs [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8955152] Function and regulation of cullin-RING ubiquitin ligases [LiteratureReference:8955166] RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis [LiteratureReference:5691158] CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex [LiteratureReference:208138] Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex [LiteratureReference:8953214] NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases [LiteratureReference:8955206] TIP120A associates with cullins and modulates ubiquitin ligase activity [LiteratureReference:5691186] Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases [LiteratureReference:8953197] F-box-directed CRL complex assembly and regulation by the CSN and CAND1 [LiteratureReference:8953164] Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins [LiteratureReference:8952201] Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation [LiteratureReference:8955154] Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation [LiteratureReference:8955158] Neddylation-induced conformational control regulates cullin RING ligase activity in vivo [LiteratureReference:8955437] CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire [LiteratureReference:8955463] CSN- and CAND1-dependent remodelling of the budding yeast SCF complex
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
negativePrecedingEvent	[NegativePrecedingEvent:9767174] Futile Cycle: COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
orthologousEvent	[Reaction:R-SPO-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Schizosaccharomyces pombe [Reaction:R-DDI-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Dictyostelium discoideum [Reaction:R-CEL-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Caenorhabditis elegans [Reaction:R-DME-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Drosophila melanogaster [Reaction:R-GGA-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Gallus gallus [Reaction:R-XTR-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Xenopus tropicalis [Reaction:R-DRE-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Danio rerio [Reaction:R-SSC-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Sus scrofa [Reaction:R-BTA-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Bos taurus [Reaction:R-CFA-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Canis familiaris [Reaction:R-RNO-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Rattus norvegicus [Reaction:R-MMU-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Mus musculus
output	[Complex:R-HSA-8955244] CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8955245
summation	[Summation:8955236] CRL complexes consist of a cullin protein (CUL1, 2, 3, 4A, 4...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex

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