Reactome | COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex

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COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10635982
displayName	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
eventOf	[Pathway:R-DRE-8951664] Neddylation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Danio rerio
inferredFrom	[Reaction:R-HSA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-DRE-8955650] COMMDs:CCDC22 [nucleoplasm] [Complex:R-DRE-8955244] CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
output	[EntityWithAccessionedSequence:R-DRE-8955089] cand1 [nucleoplasm] [Complex:R-DRE-8955268] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm]
precedingEvent	[Reaction:R-DRE-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-8955285
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8951664] Neddylation
(precedingEvent)	[Reaction:R-DRE-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
(inferredTo)	[Reaction:R-HSA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex

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