Reactome | NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex

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NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8952636] Rothfels, Karen, 2016-12-15
dbId	8952639
displayName	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-HSA-8955268] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] [CandidateSet:R-HSA-8952551] DCUN1D1,2,4,5 [nucleoplasm] [Complex:R-HSA-8952569] NEDD8-AcM-UBE2M [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8952185] E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification [LiteratureReference:8952007] Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes [LiteratureReference:8952191] SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation [LiteratureReference:8952178] Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation [LiteratureReference:8952208] The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes [LiteratureReference:8952170] Characterization of the mammalian family of DCN-type NEDD8 E3 ligases [LiteratureReference:8955468] SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1) [LiteratureReference:5690803] Protein neddylation: beyond cullin-RING ligases [LiteratureReference:8955148] Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B [LiteratureReference:8955171] The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications [LiteratureReference:8953189] Cullin E3 ligases and their rewiring by viral factors
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
orthologousEvent	[Reaction:R-DDI-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Dictyostelium discoideum [Reaction:R-DME-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Drosophila melanogaster [Reaction:R-DRE-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-BTA-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-RNO-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Rattus norvegicus [Reaction:R-MMU-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Mus musculus
output	[Complex:R-HSA-8952580] NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8951661] Transfer of NEDD8 to AcM-UBE2M - Homo sapiens [Reaction:R-HSA-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952639
summation	[Summation:8955256] UBE2M is the E2 for CRL complexes containing cullin 1, 2, 3 ...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex

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