Reactome | TPST1,2 transfer SO4(2-) from PAPS to PODXL2

Schema > Reaction > Entries

TPST1,2 transfer SO4(2-) from PAPS to PODXL2 Show undefined attributes

authored	[InstanceEdit:8954264] Jassal, Bijay, 2017-01-06
catalystActivity	[CatalystActivity:8954238] protein-tyrosine sulfotransferase activity of TPST1,2 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:8954264] Jassal, Bijay, 2017-01-06
dbId	8954262
displayName	TPST1,2 transfer SO4(2-) from PAPS to PODXL2
edited	[InstanceEdit:8954264] Jassal, Bijay, 2017-01-06
eventOf	[Pathway:R-HSA-156584] Cytosolic sulfonation of small molecules - Homo sapiens
followingEvent	[Reaction:R-HSA-8953499] IMPAD1 hydrolyses PAP to AMP - Homo sapiens
input	2 × [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-8954248] PODXL2 [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8954239] Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x [LiteratureReference:8954263] Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins [LiteratureReference:8954257] Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2 [LiteratureReference:8954260] Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction [LiteratureReference:8954252] Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TPST1,2 transfer SO4(2-) from PAPS to PODXL2
orthologousEvent	[Reaction:R-GGA-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Gallus gallus [Reaction:R-XTR-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Xenopus tropicalis [Reaction:R-SSC-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Sus scrofa [Reaction:R-BTA-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Bos taurus [Reaction:R-CFA-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Canis familiaris [Reaction:R-RNO-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Rattus norvegicus [Reaction:R-MMU-8954262] TPST1,2 transfer SO4(2-) from PAPS to PODXL2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8954273] OSulf-Y97,118-PODXL2 [Golgi lumen] 2 × [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8954262
summation	[Summation:8954246] Podocalyxin-like protein 2 (PODXL2 aka endoglycan) acts as a...

Referrals

(hasEvent)	[Pathway:R-HSA-156584] Cytosolic sulfonation of small molecules
(precedingEvent)	[Reaction:R-HSA-8953499] IMPAD1 hydrolyses PAP to AMP