Reactome | RUNX3 regulates p14-ARF

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RUNX3 regulates p14-ARF Show undefined attributes

authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
created	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
dbId	8951936
displayName	RUNX3 regulates p14-ARF
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8951951] RUNX3 binds EP300 - Homo sapiens [Reaction:R-HSA-8951966] EP300 acetylates RUNX3 - Homo sapiens [Reaction:R-HSA-8951977] Acetylated RUNX3 binds to BRD2 - Homo sapiens [Reaction:R-HSA-8952081] RUNX proteins bind the p14-ARF promoter at the CDKN2A locus - Homo sapiens [BlackBoxEvent:R-HSA-8952101] p14-ARF transcription is stimulated by RUNX proteins - Homo sapiens [Reaction:R-HSA-8952058] CCND1 binds RUNX3 and displaces EP300 - Homo sapiens [Reaction:R-HSA-8952062] CCND1 recruits HDAC4 to RUNX3 - Homo sapiens [Reaction:R-HSA-8952069] HDAC4 deacetylates RUNX3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8951941] Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RUNX3 regulates p14-ARF
orthologousEvent	[Pathway:R-CEL-8951936] RUNX3 regulates p14-ARF - Caenorhabditis elegans [Pathway:R-DME-8951936] RUNX3 regulates p14-ARF - Drosophila melanogaster [Pathway:R-GGA-8951936] RUNX3 regulates p14-ARF - Gallus gallus [Pathway:R-XTR-8951936] RUNX3 regulates p14-ARF - Xenopus tropicalis [Pathway:R-DRE-8951936] RUNX3 regulates p14-ARF - Danio rerio [Pathway:R-SSC-8951936] RUNX3 regulates p14-ARF - Sus scrofa [Pathway:R-BTA-8951936] RUNX3 regulates p14-ARF - Bos taurus [Pathway:R-CFA-8951936] RUNX3 regulates p14-ARF - Canis familiaris [Pathway:R-RNO-8951936] RUNX3 regulates p14-ARF - Rattus norvegicus [Pathway:R-MMU-8951936] RUNX3 regulates p14-ARF - Mus musculus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8951936
summation	[Summation:8952889] Acetylation of RUNX3 by the histone acetyl transferase p300 ...

Referrals

(hasEvent)

[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3