RUNX3 regulates p14-ARF

Stable Identifier
R-HSA-8951936
Type
Pathway
Species
Homo sapiens
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Summation

Acetylation of RUNX3 by the histone acetyl transferase p300 (EP300) and the subsequent association of acetylated RUNX3 with BRD2 correlates with upregulation of p14-ARF transcription from the CDKN2A locus. Cyclin D1 (CCND1) negatively regulates RUNX3-facilitated induction of p14-ARF by recruiting histone deacetylase HDAC4 to RUNX3, leading to RUNX3 deacetylation (Lee et al. 2013).

Literature References
PubMed ID Title Journal Year
24229708 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma

Lee, YS, Lee, JW, Jang, JW, Chi, XZ, Kim, JH, Li, YH, Kim, MK, Kim, DM, Choi, BS, Kim, EG, Chung, JH, Lee, OJ, Lee, YM, Suh, JW, Chuang, LS, Ito, Y, Bae, SC

Cancer Cell 2013
Participants
Participant Of
Orthologous Events
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Reviewed