Reactome | Doubly neddylated UBA3:NAE1 binds AcM-UBE2M

Schema > Reaction > Entries

Doubly neddylated UBA3:NAE1 binds AcM-UBE2M Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8951750] Rothfels, Karen, 2016-12-09
dbId	8951751
displayName	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8951661] Transfer of NEDD8 to AcM-UBE2M - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8951627] AcM-UBE2M [cytosol] [Complex:R-HSA-8951658] NEDD8-UBA3:NAE1:NEDD8 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8951615] A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 [LiteratureReference:8951620] Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity [LiteratureReference:5690803] Protein neddylation: beyond cullin-RING ligases [LiteratureReference:8952185] E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M
negativePrecedingEvent	[NegativePrecedingEvent:9767181] Futile Cycle: AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex [NegativePrecedingEvent:9767182] Futile Cycle: AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex [NegativePrecedingEvent:9767180] Futile Cycle: AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex [NegativePrecedingEvent:9767183] Futile Cycle: AcM-UBE2M transfers NEDD8 to CUL9:RBX1
output	[Complex:R-HSA-8951749] AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol]
precedingEvent	[Reaction:R-HSA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8951751
summation	[Summation:8952614] When NAE1:UBA3 is doubly loaded with NEDD8 (one molecule cov...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8951661] Transfer of NEDD8 to AcM-UBE2M

Cite Us!