Y693-STAT4 dimer translocates to the nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
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Once activated by tyrosine phosphorylation, Signal transducer and activator of transcription 4 (STAT4) forms a homodimer, translocates to the nucleus, binds to specific DNA sequences representing an IFN-gamma response element (also known as gamma-interferon-activation sites (GAS)) (Bacon et al. 1995). Using electrophoretic mobility shift assay (EMSA), confocal laser microscopy and Western blotting, nuclear translocation of STAT4 in response to Interleukin-12 (IL12) has been demonstrated in Phytohaemagglutinin (PHA) activated T cells (Toyoda et al. 2004). Using confocal laser microscopy, nuclear translocation of STAT4 in response to IL12 has also been demonstrated in B cells(Durali et al. 2003)

Translocation to the nucleus is presented as a black box event because the exact mechanism of translocation is unknown.
Literature References
PubMed ID Title Journal Year
15004198 Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection

Kisenge, RR, Hayashi, T, Nakano, T, Kamiya, H, Toyoda, H, Komada, Y, Hori, H, Chipeta, J, Kang, J, Tanaka, S, Bu, J, Suzuki, K, Ido, M, Gabazza, EC

J. Immunol. 2004
9890938 Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling

Hoey, T, McKinney, J, Salvekar, A, Naeger, LK

J. Biol. Chem. 1999
Orthologous Events
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