Reactome | Y693-STAT4 dimer translocates to the nucleus

Y693-STAT4 dimer translocates to the nucleus

Stable Identifier

R-HSA-8950181

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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Y693-STAT4 dimer translocates to the nucleus

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Once activated by tyrosine phosphorylation, Signal transducer and activator of transcription 4 (STAT4) forms a homodimer, translocates to the nucleus, binds to specific DNA sequences representing an IFN-gamma response element (also known as gamma-interferon-activation sites (GAS)) (Bacon et al. 1995). Using electrophoretic mobility shift assay (EMSA), confocal laser microscopy and Western blotting, nuclear translocation of STAT4 in response to Interleukin-12 (IL12) has been demonstrated in Phytohaemagglutinin (PHA) activated T cells (Toyoda et al. 2004). Using confocal laser microscopy, nuclear translocation of STAT4 in response to IL12 has also been demonstrated in B cells(Durali et al. 2003)

Translocation to the nucleus is presented as a black box event because the exact mechanism of translocation is unknown.

Literature References

PubMed ID	Title	Journal	Year
15004198	Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection Kisenge, RR, Hayashi, T, Nakano, T, Kamiya, H, Toyoda, H, Komada, Y, Hori, H, Chipeta, J, Kang, J, Tanaka, S, Bu, J, Suzuki, K, Ido, M, Gabazza, EC	J. Immunol.	2004
9890938	Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling Hoey, T, McKinney, J, Salvekar, A, Naeger, LK	J. Biol. Chem.	1999