Reactome | Once activated by tyrosine phosphorylation, Signal transduce...

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created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
dbId	8950641
displayName	Once activated by tyrosine phosphorylation, Signal transduce...
literatureReference	[LiteratureReference:6804709] Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes [LiteratureReference:8950667] Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection [LiteratureReference:8981052] In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment
modified	[InstanceEdit:9006617] Jupe, Steve, 2017-05-17
schemaClass	Summation
text	Once activated by tyrosine phosphorylation, Signal transducer and activator of transcription 4 (STAT4) forms a homodimer, translocates to the nucleus, binds to specific DNA sequences representing an IFN-gamma response element (also known as gamma-interferon-activation sites (GAS)) (Bacon et al. 1995). Using electrophoretic mobility shift assay (EMSA), confocal laser microscopy and Western blotting, nuclear translocation of STAT4 in response to Interleukin-12 (IL12) has been demonstrated in Phytohaemagglutinin (PHA) activated T cells (Toyoda et al. 2004). Using confocal laser microscopy, nuclear translocation of STAT4 in response to IL12 has also been demonstrated in B cells(Durali et al. 2003) Translocation to the nucleus is presented as a black box event because the exact mechanism of translocation is unknown.

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