PTEN mRNA translation is negatively regulated by microRNAs

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Homo sapiens
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PTEN protein synthesis is negatively regulated by microRNAs miR-26A1 and miR-26A2, which recruit the RISC complex to PTEN mRNA. Overexpression of miR-26A2, caused by genomic amplification of MIR26A2 locus on chromosome 12, is frequently observed in human brain glioma tumors possessing one wild-type PTEN allele, and is thought to contribute to tumor progression by repressing PTEN protein expression from the remaining allele (Huse et al. 2009). Other microRNAs, which may also be altered in cancer, such as miR-17, miR-19a, miR-19b, miR-20a, miR-20b, miR-21, miR-22, miR-25, miR-93, miR-106a, miR-106b, miR 205, and miR 214, also bind PTEN mRNA and inhibit its translation into protein (Meng et al. 2007, Xiao et al. 2008, Yang et al. 2008, Kim et al. 2010, Poliseno, Salmena, Riccardi et al. 2010, Zhang et al. 2010, Tay et al. 2011, Qu et al. 2012, Cai et al. 2013).

Literature References
PubMed ID Title Journal Year
18199536 MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

Kong, W, O'Donnell, JD, Kruk, PA, Zhao, JJ, He, L, Wenham, RM, Cheng, JQ, Nicosia, SV, Coppola, D, Wang, J, Yang, H

Cancer Res. 2008
20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Rameh, L, Varmeh, S, Sportoletti, P, Fornari, A, Loda, M, Poliseno, L, Fedele, G, Song, MS, Riccardi, L, Hobbs, RM, Pandolfi, PP, Egia, A, Salmena, L

Sci Signal 2010
23856247 miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer

Cai, J, Huang, Y, Li, R, Yang, Y, Yuan, J, Fang, L, Li, M, Chen, B, Zhu, X, Wu, J

Cancer Res. 2013
22374676 MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN

Liang, Z, Zhang, R, Huang, J, Wang, X, Su, C, Qu, C, Lee, MH, Zhao, R, Wang, S, Yang, H

Cell Cycle 2012
20223231 MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

Yang, GH, Liu, Q, Wang, JJ, Zhang, JG, Jiang, K, Zhao, F

Clin. Chim. Acta 2010
17681183 MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

Wehbe-Janek, H, Patel, T, Meng, F, Henson, R, Jacob, ST, Ghoshal, K

Gastroenterology 2007
19487573 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

Rouhanifard, SH, le Sage, C, Hambardzumyan, D, Brennan, C, Holland, EC, Sohn-Lee, C, Pena, J, Agami, R, Huse, JT, Tuschl, T, Wee, B

Genes Dev. 2009
18327259 Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

Zhang, B, Xiao, C, Kutok, JL, Henderson, JM, Wang, J, Calado, DP, Srinivasan, L, Rajewsky, K, Patterson, HC

Nat. Immunol. 2008
20080666 Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

Park, PJ, Johnson, MD, Jiang, X, Kim, H, Huang, W, Pennicooke, B

Proc. Natl. Acad. Sci. U.S.A. 2010
22000013 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Weiss, D, Karreth, F, Tan, SM, Di Cunto, F, Rigoutsos, I, Provero, P, Ala, U, Kats, L, Poliseno, L, Tay, Y, Pandolfi, PP, Lieberman, J, Salmena, L

Cell 2011
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