Reactome | Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

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Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation Show undefined attributes

author	[Person:8943355] Poliseno, L [Person:5690166] Salmena, L [Person:8943353] Riccardi, L [Person:8943356] Fornari, A [Person:110803] Song, MS [Person:8943352] Hobbs, RM [Person:8943348] Sportoletti, P [Person:8943349] Varmeh, S [Person:5690110] Egia, A [Person:8943354] Fedele, G [Person:8943350] Rameh, L [Person:2460054] Loda, M [Person:5690201] Pandolfi, PP
created	[InstanceEdit:8943347] Orlic-Milacic, Marija, 2016-10-25
dbId	8943351
displayName	Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
journal	Sci Signal
pages	ra29
pubMedIdentifier	20388916
schemaClass	LiteratureReference
title	Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
url	http://www.ncbi.nlm.nih.gov/pubmed/20388916
volume	3
year	2010

Referrals

(literatureReference)

[Pathway:R-HSA-6807070] PTEN Regulation
[Pathway:R-HSA-8943723] Regulation of PTEN mRNA translation
[BlackBoxEvent:R-HSA-8944497] PTEN mRNA translation is negatively regulated by microRNAs
[Reaction:R-HSA-8944599] miR-93 microRNA binds PTEN mRNA
[Reaction:R-HSA-8944483] miR-17 microRNA binds PTEN mRNA
[Reaction:R-HSA-8944538] miR-22 microRNA binds PTEN mRNA
[Reaction:R-HSA-8944522] miR-19a microRNA binds PTEN mRNA
[Reaction:R-HSA-8944569] miR-25 microRNA binds PTEN mRNA
[Reaction:R-HSA-8944632] miR-106 microRNAs bind PTEN mRNA
[RegulationReference:9641817] Negative gene expression regulation by 'miR-106 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
[RegulationReference:9641291] Negative gene expression regulation by 'miR-22 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
[RegulationReference:9641604] Negative gene expression regulation by 'miR-17 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
[RegulationReference:9642645] Negative gene expression regulation by 'miR-93:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
[RegulationReference:9641958] Negative gene expression regulation by 'miR-19a RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
[RegulationReference:9642583] Negative gene expression regulation by 'miR-25 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
[RegulationReference:9641697] Negative gene expression regulation by 'miR-19b RISC:PTEN mRNA [cytosol]' Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
[Complex:R-HSA-8944565] miR-25 RISC:PTEN mRNA [cytosol]
[Complex:R-HSA-8944631] miR-106 RISC:PTEN mRNA [cytosol]
[Complex:R-HSA-8944600] miR-93:PTEN mRNA [cytosol]
[Complex:R-HSA-8944487] miR-17 RISC:PTEN mRNA [cytosol]
[Complex:R-HSA-8944551] miR-22 RISC:PTEN mRNA [cytosol]
[Complex:R-HSA-8944524] miR-19a RISC:PTEN mRNA [cytosol]

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