MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter

Stable Identifier
R-HSA-8943817
Type
Reaction [binding]
Species
Homo sapiens
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The transcription factor MECOM (EVI1) can associate with the polycomb repressor complexes (PRCs) and recruit them to the promoter of the PTEN gene (Song et al. 2009). Both the BMI1-containing PRC, supposedly PRC1.4, and the EZH2-containing PRC2 complex are recruited to the PTEN promoter, resulting in transcriptional silencing of the PTEN gene (Song et al. 2009, Yoshimi et al. 2011). Since the exact composition of the EZH2-containing PRC2 at the PTEN promoter is not known, the core EZH2-PRC2 complex is shown.

Literature References
PubMed ID Title Journal Year
21289308 Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

Yoshimi, A, Goyama, S, Watanabe-Okochi, N, Yoshiki, Y, Nannya, Y, Nitta, E, Arai, S, Sato, T, Shimabe, M, Nakagawa, M, Imai, Y, Kitamura, T, Kurokawa, M

Blood 2011
19884659 The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

Song, LB, Li, J, Liao, WT, Feng, Y, Yu, CP, Hu, LJ, Kong, QL, Xu, LH, Zhang, X, Liu, WL, Li, MZ, Zhang, L, Kang, TB, Fu, LW, Huang, WL, Xia, YF, Tsao, SW, Li, M, Band, V, Band, H, Shi, QH, Zeng, YX, Zeng, MS

J. Clin. Invest. 2009
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