Reactome | SALL4 recruits NuRD to PTEN gene

SALL4 recruits NuRD to PTEN gene

Stable Identifier

R-HSA-8943780

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SALL4 recruits the transcriptional repressor complex NuRD, containing histone deacetylases HDAC1 and HDAC2, to the PTEN gene promoter (Lu et al 2009, Gao et al. 2013). SALL4 may also recruit DNA methyltransferases (DNMTs) to the PTEN promoter (Yang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23287862	Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex Gao, C, Dimitrov, T, Yong, KJ, Tatetsu, H, Jeong, HW, Luo, HR, Bradner, JE, Tenen, DG, Chai, L	Blood	2013
19440552	Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex Lu, J, Jeong, HW, Kong, N, Yang, Y, Carroll, J, Luo, HR, Silberstein, LE, Yupoma, LE, Chai, L	PLoS One	2009