Reactome | SALL4 recruits NuRD to PTEN gene

SALL4 recruits NuRD to PTEN gene

Stable Identifier

R-HSA-8943780

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SALL4 recruits the transcriptional repressor complex NuRD, containing histone deacetylases HDAC1 and HDAC2, to the PTEN gene promoter (Lu et al 2009, Gao et al. 2013). SALL4 may also recruit DNA methyltransferases (DNMTs) to the PTEN promoter (Yang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23287862	Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex Tatetsu, H, Dimitrov, T, Bradner, JE, Jeong, HW, Gao, C, Yong, KJ, Luo, HR, Chai, L, Tenen, DG	Blood	2013
19440552	Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex Jeong, HW, Silberstein, LE, Carroll, J, Chai, L, Yang, Y, Kong, N, Lu, J, Luo, HR, Yupoma, LE	PLoS One	2009