SALL4 recruits NuRD to PTEN gene

Stable Identifier
R-HSA-8943780
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SALL4 recruits the transcriptional repressor complex NuRD, containing histone deacetylases HDAC1 and HDAC2, to the PTEN gene promoter (Lu et al 2009, Gao et al. 2013). SALL4 may also recruit DNA methyltransferases (DNMTs) to the PTEN promoter (Yang et al. 2012).

Literature References
PubMed ID Title Journal Year
19440552 Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex

Lu, J, Jeong, HW, Kong, N, Yang, Y, Carroll, J, Luo, HR, Silberstein, LE, Yupoma, LE, Chai, L

PLoS One 2009
23287862 Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

Gao, C, Dimitrov, T, Yong, KJ, Tatetsu, H, Jeong, HW, Luo, HR, Bradner, JE, Tenen, DG, Chai, L

Blood 2013
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