Reactome | RAD18:UBE2B [nucleoplasm]

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RAD18:UBE2B [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-8943053] HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] - Homo sapiens [Complex:R-HSA-8943018] SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8943041] HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N - Homo sapiens [Reaction:R-HSA-8943007] SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N - Homo sapiens
created	[InstanceEdit:5643742] Orlic-Milacic, Marija, 2014-11-17
dbId	5643741
displayName	RAD18:UBE2B [nucleoplasm]
hasComponent	[Complex:R-HSA-5643735] RAD18 homodimer [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-5643739] UBE2B [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-5643741] RAD18:UBE2B [nucleoplasm] - Mus musculus [Complex:R-RNO-5643741] RAD18:UBE2B [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-5643741] RAD18:UBE2B [nucleoplasm] - Canis familiaris [Complex:R-BTA-5643741] RAD18:UBE2B [nucleoplasm] - Bos taurus [Complex:R-SSC-5643741] RAD18:UBE2B [nucleoplasm] - Sus scrofa [Complex:R-DRE-5643741] RAD18:UBE2B [nucleoplasm] - Danio rerio [Complex:R-GGA-5643741] RAD18:UBE2B [nucleoplasm] - Gallus gallus [Complex:R-DME-5643741] RAD18:UBE2B [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-5643741] RAD18:UBE2B [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-5643741] RAD18:UBE2B [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-5643741] RAD18:UBE2B [nucleoplasm] - Schizosaccharomyces pombe
isChimeric	false
literatureReference	[LiteratureReference:5643738] Symmetry and asymmetry of the RING-RING dimer of Rad18 [LiteratureReference:5651988] Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification
maxDepth	3
memberOf	[DefinedSet:R-HSA-5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:5652006] Orlic-Milacic, Marija, 2014-11-26
name	RAD18:UBE2B RAD18:RAD6B
producedByEvent	[BlackBoxEvent:R-HSA-8943040] HLTF polyubiquitinates monoubiquitinated PCNA - Homo sapiens [BlackBoxEvent:R-HSA-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5643741

Referrals

(input)	[Reaction:R-HSA-8943007] SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N [Reaction:R-HSA-8943041] HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
(output)	[BlackBoxEvent:R-HSA-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA [BlackBoxEvent:R-HSA-8943040] HLTF polyubiquitinates monoubiquitinated PCNA
(hasComponent)	[Complex:R-HSA-8943018] SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] [Complex:R-HSA-8943053] HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm]
(hasMember)	[DefinedSet:R-HSA-5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm]
(activeUnit)	[CatalystActivity:5652007] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]

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