Reactome | RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

Stable Identifier

R-HSA-8942099

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

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The ubiquitin E3 ligase complex RNF20:RNF40 (also known as Bre1 in Saccharomyces cerevisiae) interacts with the PAF complex and the E2-ubiquitin conjugate UBE2A,B:Ubiquitin (RAD6:Ubiquitin in Saccharomyces cerevisiae) (Zhu et al. 2005, Kim et al. 2009, Hahn et al. 2012, Foglizzo et al. 2016). The complex binds nucleosomal histone H2B after which RNF20:RNF40 monoubiquitinates histone H2B (Zhu et al. 2005, Kim et al. 2009). RNF20:RNF40 also binds WAC, which targets RNF20:RNF40 to the RNA polymerase II complex and promotes monoubiquitination of histone H2B (Zhang and Yu 2011).

Literature References

PubMed ID	Title	Journal	Year
19410543	RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells Kim, J, Shilatifard, A, Tang, Z, Roeder, RG, Guermah, M, Milne, TA, Lee, JS, Muir, TW, McGinty, RK	Cell	2009
16307923	Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation Pham, AD, Zheng, Y, Reinberg, D, Mandal, SS, Tempst, P, Erdjument-Bromage, H, Zhu, B	Mol. Cell	2005
22021426	The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination Marsh, DJ, Jackson, S, Clarkson, A, Dickson, KA, Gill, AJ, Hahn, MA	Hum. Mol. Genet.	2012
21329877	WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription Yu, X, Zhang, F	Mol. Cell	2011
27569044	Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B Foglizzo, M, Day, CL, Middleton, AJ	J. Mol. Biol.	2016