Reactome | RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

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RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10716739
displayName	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B
eventOf	[Pathway:R-XTR-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-XTR-8942101] RNF20:RNF40 monoubiquitinates Histone H2B - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Homo sapiens
input	[DefinedSet:R-XTR-4549207] Histone HIST1H2B [nucleoplasm] [Complex:R-XTR-8866690] PAF1C [nucleoplasm] [Complex:R-XTR-8942086] RNF20:RNF40 [nucleoplasm] [Complex:R-XTR-8942129] Ub:UBE2A,B [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-8942150] wac [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B
output	[Complex:R-XTR-8942094] PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8942099
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8866654] E3 ubiquitin ligases ubiquitinate target proteins
(precedingEvent)	[BlackBoxEvent:R-XTR-8942101] RNF20:RNF40 monoubiquitinates Histone H2B
(inferredTo)	[Reaction:R-HSA-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

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