Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAS nucleotide is stimulated downstream of activated FGFR4 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).

Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
17227708 The role of Shp2 (PTPN11) in cancer

Mohi, MG, Neel, BG

Curr. Opin. Genet. Dev. 2007
18452557 Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

Gotoh, N

Cancer Sci 2008
Participant Of
This event is regulated
Orthologous Events
Cite Us!