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Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
Stable Identifier
R-HSA-8941613
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RAS nucleotide is stimulated downstream of activated FGFR4 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).
Literature References
PubMed ID
Title
Journal
Year
17227708
The role of Shp2 (PTPN11) in cancer
Neel, BG
,
Mohi, MG
Curr. Opin. Genet. Dev.
2007
9632781
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
Schlessinger, J
,
Kouhara, H
,
Lax, I
,
Hadari, YR
Mol Cell Biol
1998
18452557
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
Gotoh, N
Cancer Sci
2008
Participants
Input
GTP [cytosol]
p21 RAS:GDP [plasma membrane]
(Homo sapiens)
Output
GDP [cytosol]
p21 RAS:GTP [plasma membrane]
(Homo sapiens)
Participates
as an event of
FRS-mediated FGFR4 signaling (Homo sapiens)
This event is regulated
Requirements
Requirement by 'Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane]'
Orthologous Events
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
Authored
Rothfels, K (2011-08-15)
Reviewed
Gotoh, N (2011-08-26)
Created
Rothfels, K (2016-10-05)
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