Reactome | Events associated with phagocytolytic activity of PMN cells

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Events associated with phagocytolytic activity of PMN cells Show undefined attributes

authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
created	[InstanceEdit:8941414] Shamovsky, Veronica, 2016-09-30
dbId	8941413
displayName	Events associated with phagocytolytic activity of PMN cells
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
eventOf	[Pathway:R-HSA-1222556] ROS and RNS production in phagocytes - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Homo sapiens [Reaction:R-HSA-6788974] Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) - Homo sapiens [Reaction:R-HSA-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Homo sapiens [BlackBoxEvent:R-HSA-6789136] Myeloperoxidase (MPO) binds to the bacterial cell surface - Homo sapiens [Reaction:R-HSA-6789031] Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Homo sapiens [Reaction:R-HSA-6789185] Chloride ion and N-acyl group react to chloramide - Homo sapiens [BlackBoxEvent:R-HSA-6789208] HOCl-induced glycosaminoglycan fragmentation - Homo sapiens [Reaction:R-HSA-6789218] Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins - Homo sapiens [Reaction:R-HSA-9625548] Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride - Homo sapiens [Reaction:R-HSA-9625540] Cys-sulfenyl chloride is converted to Cys-sulfenic acid - Homo sapiens [Reaction:R-HSA-9625904] Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine - Homo sapiens [Reaction:R-HSA-9625913] Hypochlorous acid (HOCL) reacts with Lys-monochloramine - Homo sapiens [Reaction:R-HSA-8855490] Lactoperoxidase (LPO) produces OSCN- - Homo sapiens [Reaction:R-HSA-8941411] OSCN- reacts with Cys residues - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8942013] Reactive Oxygen Species and Neutrophil Function [LiteratureReference:6789116] Redox reactions and microbial killing in the neutrophil phagosome
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Events associated with phagocytolytic activity of PMN cells
orthologousEvent	[Pathway:R-MMU-8941413] Events associated with phagocytolytic activity of PMN cells - Mus musculus [Pathway:R-DDI-8941413] Events associated with phagocytolytic activity of PMN cells - Dictyostelium discoideum [Pathway:R-CEL-8941413] Events associated with phagocytolytic activity of PMN cells - Caenorhabditis elegans [Pathway:R-DME-8941413] Events associated with phagocytolytic activity of PMN cells - Drosophila melanogaster [Pathway:R-GGA-8941413] Events associated with phagocytolytic activity of PMN cells - Gallus gallus [Pathway:R-XTR-8941413] Events associated with phagocytolytic activity of PMN cells - Xenopus tropicalis [Pathway:R-SSC-8941413] Events associated with phagocytolytic activity of PMN cells - Sus scrofa [Pathway:R-BTA-8941413] Events associated with phagocytolytic activity of PMN cells - Bos taurus [Pathway:R-CFA-8941413] Events associated with phagocytolytic activity of PMN cells - Canis familiaris [Pathway:R-RNO-8941413] Events associated with phagocytolytic activity of PMN cells - Rattus norvegicus
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8941413
summation	[Summation:8941415] When neutrophils engulf bacteria they enclose them in small ...

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[Pathway:R-HSA-1222556] ROS and RNS production in phagocytes

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