Reactome | Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide

Schema > Reaction > Entries

Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide Show undefined attributes

authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
catalystActivity	[CatalystActivity:6789103] peroxidase activity of MPO:ferriheme [phagocytic vesicle lumen]
category	transition
compartment	[Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:8933633] Shamovsky, Veronica, 2016-08-08
dbId	8933635
displayName	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
eventOf	[Pathway:R-HSA-8941413] Events associated with phagocytolytic activity of PMN cells - Homo sapiens
input	2 × [SimpleEntity:R-ALL-1470067] H+ [phagocytic vesicle lumen] [SimpleEntity:R-ALL-1222719] H2O2 [phagocytic vesicle lumen] 2 × [SimpleEntity:R-ALL-6789221] nitrite [phagocytic vesicle lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8933642] Mechanism of reaction of myeloperoxidase with nitrite [LiteratureReference:8933643] The role of nitrite ion in phagocyte function--perspectives and puzzles [LiteratureReference:6803564] Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide
orthologousEvent	[Reaction:R-MMU-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Mus musculus [Reaction:R-DDI-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Dictyostelium discoideum [Reaction:R-CEL-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Caenorhabditis elegans [Reaction:R-DME-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Drosophila melanogaster [Reaction:R-GGA-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Gallus gallus [Reaction:R-XTR-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Xenopus tropicalis [Reaction:R-SSC-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Sus scrofa [Reaction:R-BTA-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Bos taurus [Reaction:R-CFA-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Canis familiaris [Reaction:R-RNO-8933635] Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-1222475] H2O [phagocytic vesicle lumen] 2 × [SimpleEntity:R-ALL-8933637] NO2 [phagocytic vesicle lumen]
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8933635
summation	[Summation:8933634] Nitrite (NO2-) is the primary metabolic end product of nitri...

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[Pathway:R-HSA-8941413] Events associated with phagocytolytic activity of PMN cells