Reactome | Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)

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Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) Show undefined attributes

authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
catalystActivity	[CatalystActivity:6789103] peroxidase activity of MPO:ferriheme [phagocytic vesicle lumen]
category	transition
compartment	[Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:6789177] Shamovsky, Veronica, 2015-07-29
crossReference	[DatabaseIdentifier:12667923] RHEA:28219
dbId	6789126
displayName	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
eventOf	[Pathway:R-HSA-8941413] Events associated with phagocytolytic activity of PMN cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9625548] Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride - Homo sapiens [Reaction:R-HSA-6788974] Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) - Homo sapiens [Reaction:R-HSA-9625904] Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine - Homo sapiens
input	[SimpleEntity:R-ALL-6788973] Cl- [phagocytic vesicle lumen] [SimpleEntity:R-ALL-1470067] H+ [phagocytic vesicle lumen] [SimpleEntity:R-ALL-1222719] H2O2 [phagocytic vesicle lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803668] Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids [LiteratureReference:6803564] Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention [LiteratureReference:6789156] X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution [LiteratureReference:6789139] Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing [LiteratureReference:6806057] Myeloperoxidase: a front-line defender against phagocytosed microorganisms
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
orthologousEvent	[Reaction:R-MMU-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Mus musculus [Reaction:R-DDI-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Dictyostelium discoideum [Reaction:R-CEL-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Caenorhabditis elegans [Reaction:R-DME-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Drosophila melanogaster [Reaction:R-GGA-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Gallus gallus [Reaction:R-XTR-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Xenopus tropicalis [Reaction:R-SSC-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Sus scrofa [Reaction:R-BTA-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Bos taurus [Reaction:R-CFA-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Canis familiaris [Reaction:R-RNO-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Rattus norvegicus
output	[SimpleEntity:R-ALL-1222475] H2O [phagocytic vesicle lumen] [SimpleEntity:R-ALL-6789150] HOCl [phagocytic vesicle lumen]
precedingEvent	[Reaction:R-HSA-6789092] NOX2 generates superoxide anion from oxygen - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6789126
summation	[Summation:6803681] Phagosomal myeloperoxidase (MPO) is an important heme enzyme...

Referrals

(precedingEvent)	[Reaction:R-HSA-9625548] Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride [Reaction:R-HSA-6788974] Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) [Reaction:R-HSA-9625904] Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine
(hasEvent)	[Pathway:R-HSA-8941413] Events associated with phagocytolytic activity of PMN cells

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