SRC,YES1 phosphorylate YAP1

Stable Identifier
R-HSA-8937844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SRC,YES1 phosphorylate YAP1
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Based on studies in rat, activated SRC and/or YES1 tyrosine kinases phosphorylate YAP1 on an unknown tyrosine residue (Zaidi et al. 2004).
Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK

EMBO J. 2004
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Src,Yes1 phosphorylate Yap1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2016-09-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)
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