Reactome | p-S13-FUNDC1 is dephosphorylated by PGAM5

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p-S13-FUNDC1 is dephosphorylated by PGAM5 Show undefined attributes

authored	[InstanceEdit:8944058] Gillespie, Marc E, 2016-11-01
catalystActivity	[CatalystActivity:8948144] protein serine/threonine phosphatase activity of PGAM5-S [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8948141] Gillespie, Marc E, 2016-11-10
dbId	8948139
displayName	p-S13-FUNDC1 is dephosphorylated by PGAM5
edited	[InstanceEdit:8980658] Gillespie, Marc E, 2017-02-28
eventOf	[Pathway:R-HSA-8934903] Receptor Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-8948039] FUNDC1 is phosphorylated by CK2 - Homo sapiens [Reaction:R-HSA-8948146] FUNDC1 is phosphorylated by ULK1 at Ser17 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8934910] p-S13-FUNDC1 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8959559] A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p-S13-FUNDC1 is dephosphorylated by PGAM5
orthologousEvent	[Reaction:R-GGA-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Gallus gallus [Reaction:R-CEL-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Caenorhabditis elegans [Reaction:R-DME-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Drosophila melanogaster [Reaction:R-DRE-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Danio rerio [Reaction:R-SSC-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Sus scrofa [Reaction:R-BTA-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Bos taurus [Reaction:R-CFA-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Canis familiaris [Reaction:R-RNO-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Rattus norvegicus [Reaction:R-MMU-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8934922] FUNDC1 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-8948039] FUNDC1 is phosphorylated by CK2 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959558] Feng, Du, 2017-01-26
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8948139
summation	[Summation:8959561] Mitochondria are selectively removed by interactions between...

Referrals

(precedingEvent)	[Reaction:R-HSA-8948146] FUNDC1 is phosphorylated by ULK1 at Ser17 [Reaction:R-HSA-8948039] FUNDC1 is phosphorylated by CK2
(hasEvent)	[Pathway:R-HSA-8934903] Receptor Mediated Mitophagy