Reactome | Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

Stable Identifier

R-HSA-8934819

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

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Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 residues. This precursor is dephosphorylated and proteolytically cleaved by several proteases, including the undefined protease PEP1 (Resing et al. 1996), mu-calpain (Yamazaki et al. 1997), furin, PCSK6 (PACE4) (Pearton et al. 2001), PRSS8 (cap1) (Leyvraz et al. 2005), ST14 (matriptase) (List et al. 2003), CELA2 (Bonnart et al. 2010), CASP14 (Denecker et al. 2007) and Kallikrein-related peptidase 5 (KLK5) (Sakabe et al. 2013). Filaggrin is further processed and proteolytically degraded by CASP14 (Eckhart & Tschachler 2011).

Literature References

PubMed ID	Title	Journal	Year
21997417	Cuts by caspase-14 control the proteolysis of filaggrin Eckhart, L, Tschachler, E	J. Invest. Dermatol.	2011
17515931	Caspase-14 protects against epidermal UVB photodamage and water loss Denecker, G, Hoste, E, Gilbert, B, Hochepied, T, Ovaere, P, Lippens, S, Van den Broecke, C, Van Damme, P, D'Herde, K, Hachem, JP, Borgonie, G, Presland, RB, Schoonjans, L, Libert, C, Vandekerckhove, J, Gevaert, K, Vandenabeele, P, Declercq, W	Nat. Cell Biol.	2007
20179351	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing Bonnart, C, Deraison, C, Lacroix, M, Uchida, Y, Besson, C, Robin, A, Briot, A, Gonthier, M, Lamant, L, Dubus, P, Monsarrat, B, Hovnanian, A	J. Clin. Invest.	2010
23629652	Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes Sakabe, J, Yamamoto, M, Hirakawa, S, Motoyama, A, Ohta, I, Tatsuno, K, Ito, T, Kabashima, K, Hibino, T, Tokura, Y	J. Biol. Chem.	2013