Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

Stable Identifier
Reaction [transition]
Homo sapiens
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Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 residues. This precursor is dephosphorylated and proteolytically cleaved by several proteases, including the undefined protease PEP1 (Resing et al. 1996), mu-calpain (Yamazaki et al. 1997), furin, PCSK6 (PACE4) (Pearton et al. 2001), PRSS8 (cap1) (Leyvraz et al. 2005), ST14 (matriptase) (List et al. 2003), CELA2 (Bonnart et al. 2010), CASP14 (Denecker et al. 2007) and Kallikrein-related peptidase 5 (KLK5) (Sakabe et al. 2013). Filaggrin is further processed and proteolytically degraded by CASP14 (Eckhart & Tschachler 2011).

Literature References
PubMed ID Title Journal Year
21997417 Cuts by caspase-14 control the proteolysis of filaggrin

Eckhart, L, Tschachler, E

J. Invest. Dermatol. 2011
17515931 Caspase-14 protects against epidermal UVB photodamage and water loss

D'Herde, K, Libert, C, Gilbert, B, Borgonie, G, Lippens, S, Declercq, W, Gevaert, K, Hoste, E, Presland, RB, Vandenabeele, P, Schoonjans, L, Ovaere, P, Hochepied, T, Hachem, JP, Van den Broecke, C, Denecker, G, Vandekerckhove, J, Van Damme, P

Nat. Cell Biol. 2007
20179351 Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

Hovnanian, A, Robin, A, Besson, C, Deraison, C, Briot, A, Bonnart, C, Monsarrat, B, Dubus, P, Uchida, Y, Gonthier, M, Lamant, L, Lacroix, M

J. Clin. Invest. 2010
23629652 Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes

Yamamoto, M, Tokura, Y, Hirakawa, S, Kabashima, K, Ohta, I, Sakabe, J, Tatsuno, K, Ito, T, Hibino, T, Motoyama, A

J. Biol. Chem. 2013
Catalyst Activity

endopeptidase activity of Cytoplasmic profilaggrin processing proteases [cytosol]

Orthologous Events
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