Reactome | Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

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Cytoplasmic proteases cleave Profilaggrin producing Filaggrin Show undefined attributes

catalystActivity	[CatalystActivity:10538266] endopeptidase activity of Cytoplasmic profilaggrin processing proteases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10538268
displayName	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
eventOf	[Pathway:R-SSC-6809371] Formation of the cornified envelope - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8942224] Filaggrin binds Keratin tonofilament:Desmosome - Sus scrofa
inferredFrom	[Reaction:R-HSA-8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-8849818] LOC110260322 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
output	[EntityWithAccessionedSequence:R-SSC-6810859] LOC110260322 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8934819
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6809371] Formation of the cornified envelope
(precedingEvent)	[Reaction:R-SSC-8942224] Filaggrin binds Keratin tonofilament:Desmosome
(inferredTo)	[Reaction:R-HSA-8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

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