Reactome | Regulation of RUNX1 Expression and Activity

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Regulation of RUNX1 Expression and Activity Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
created	[InstanceEdit:8934592] Orlic-Milacic, Marija, 2016-08-11
dbId	8934593
displayName	Regulation of RUNX1 Expression and Activity
edited	[InstanceEdit:9006087] Orlic-Milacic, Marija, 2017-05-12
eventOf	[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8938440] miR-17 binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8935930] miR-18a binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8938487] miR-20a binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8937134] miR-27a binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8938507] miR-106a binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8939129] miR-215 binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8935864] miR-302b binds RUNX1 mRNA - Homo sapiens [Reaction:R-HSA-8935766] miR-378 binds RUNX1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-8936068] H19 is cleaved to produce miR-675 - Homo sapiens [Reaction:R-HSA-8936058] miR-675 binds RUNX1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 - Homo sapiens [Reaction:R-HSA-8937682] RUNX1 binds SRC - Homo sapiens [Reaction:R-HSA-8937728] SRC phosphorylates RUNX1 - Homo sapiens [Reaction:R-HSA-8937744] PTPN11 binds p-7Y-RUNX1 - Homo sapiens [Reaction:R-HSA-8937767] PTPN11 dephosphorylates RUNX1 - Homo sapiens [Reaction:R-HSA-8938853] CDK6 binds RUNX1 - Homo sapiens [Reaction:R-HSA-8938867] CCND3,(CCND1,CCND2) binds RUNX1 - Homo sapiens [Reaction:R-HSA-8938887] PML binds RUNX1 - Homo sapiens [Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8934607] Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions [LiteratureReference:8934615] The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis [LiteratureReference:8934626] Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis [LiteratureReference:8934634] Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development [LiteratureReference:8934646] Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells [LiteratureReference:8934649] Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice [LiteratureReference:8934660] Hematopoietic stem cell fate is established by the Notch-Runx pathway [LiteratureReference:8934677] Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line [LiteratureReference:8934668] Alternative RUNX1 Promoter Regulation by Wnt/?-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors [LiteratureReference:8935825] Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary [LiteratureReference:8936033] Cis-regulatory elements are harbored in Intron5 of the RUNX1 gene [LiteratureReference:8936392] A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs [LiteratureReference:8937671] A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation [LiteratureReference:8938140] Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells [LiteratureReference:8935768] MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells [LiteratureReference:8935856] MicroRNA-302b suppresses human epithelial ovarian cancer cell growth by targeting RUNX1 [LiteratureReference:8935935] MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5 [LiteratureReference:8936054] The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1 [LiteratureReference:8937040] A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis [LiteratureReference:8939126] miR-215 promotes malignant progression of gastric cancer by targeting RUNX1 [LiteratureReference:8938443] MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation [LiteratureReference:8865313] The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo [LiteratureReference:8938862] The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3 [LiteratureReference:8938886] Physical and functional link of the leukemia-associated factors AML1 and PML [LiteratureReference:8939557] Cell cycle and developmental control of hematopoiesis by Runx1
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Regulation of RUNX1 Expression and Activity
orthologousEvent	[Pathway:R-GGA-8934593] Regulation of RUNX1 Expression and Activity - Gallus gallus [Pathway:R-XTR-8934593] Regulation of RUNX1 Expression and Activity - Xenopus tropicalis [Pathway:R-DRE-8934593] Regulation of RUNX1 Expression and Activity - Danio rerio [Pathway:R-MMU-8934593] Regulation of RUNX1 Expression and Activity - Mus musculus [Pathway:R-CEL-8934593] Regulation of RUNX1 Expression and Activity - Caenorhabditis elegans [Pathway:R-DME-8934593] Regulation of RUNX1 Expression and Activity - Drosophila melanogaster [Pathway:R-SSC-8934593] Regulation of RUNX1 Expression and Activity - Sus scrofa [Pathway:R-RNO-8934593] Regulation of RUNX1 Expression and Activity - Rattus norvegicus [Pathway:R-CFA-8934593] Regulation of RUNX1 Expression and Activity - Canis familiaris [Pathway:R-BTA-8934593] Regulation of RUNX1 Expression and Activity - Bos taurus
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8934593
summation	[Summation:8934599] At the level of transcription, expression of the RUNX1 trans...

Referrals

(hasEvent)	[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1
(hasEncapsulatedEvent)	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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