Reactome | Regulation of RUNX1 Expression and Activity

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Regulation of RUNX1 Expression and Activity Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331515
displayName	Regulation of RUNX1 Expression and Activity
eventOf	[Pathway:R-CFA-8878171] Transcriptional regulation by RUNX1 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-8937744] PTPN11 binds p-7Y-RUNX1 - Canis familiaris [Reaction:R-CFA-8937767] PTPN11 dephosphorylates RUNX1 - Canis familiaris [Reaction:R-CFA-8938853] CDK6 binds RUNX1 - Canis familiaris [Reaction:R-CFA-8938867] CCND3,(CCND1,CCND2) binds RUNX1 - Canis familiaris [Reaction:R-CFA-8938887] PML binds RUNX1 - Canis familiaris [Reaction:R-CFA-8865320] CBFB binds RUNX1 - Canis familiaris
inferredFrom	[Pathway:R-HSA-8934593] Regulation of RUNX1 Expression and Activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of RUNX1 Expression and Activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-8934593
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-8934593] Regulation of RUNX1 Expression and Activity
(hasEncapsulatedEvent)	[Pathway:R-CFA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
(hasEvent)	[Pathway:R-CFA-8878171] Transcriptional regulation by RUNX1

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