Reactome | YWHAE dimer binds phosphorylated DENND1 proteins

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YWHAE dimer binds phosphorylated DENND1 proteins Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10080596
displayName	YWHAE dimer binds phosphorylated DENND1 proteins
eventOf	[Pathway:R-MMU-8876198] RAB GEFs exchange GTP for GDP on RABs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8877612] DENND1s exchange GTP for GDP on RAB35 - Mus musculus
inferredFrom	[Reaction:R-HSA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Homo sapiens
input	[Complex:R-MMU-2262707] 14-3-3 epsilon dimer [cytosol] [CandidateSet:R-MMU-8933377] p-2S DENND1A, DENND1B [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	YWHAE dimer binds phosphorylated DENND1 proteins
output	[Complex:R-MMU-8933379] p-2S-DENND1A,B:YWHAE dimer [cytosol]
precedingEvent	[Reaction:R-MMU-8933446] Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8933452
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8876198] RAB GEFs exchange GTP for GDP on RABs
(precedingEvent)	[Reaction:R-MMU-8877612] DENND1s exchange GTP for GDP on RAB35
(inferredTo)	[Reaction:R-HSA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins

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