Reactome | HIPK2 phosphorylates RUNX1 and EP300

Schema > Reaction > Entries

HIPK2 phosphorylates RUNX1 and EP300 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
catalystActivity	[CatalystActivity:8878065] protein serine/threonine kinase activity of HIPK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878051] Orlic-Milacic, Marija, 2016-06-29
dbId	8878050
displayName	HIPK2 phosphorylates RUNX1 and EP300
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8939243] RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known - Homo sapiens
input	5 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-8878064] RUNX1:CBFB:EP300 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8878057] PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis [LiteratureReference:8878049] Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HIPK2 phosphorylates RUNX1 and EP300
orthologousEvent	[Reaction:R-MMU-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Mus musculus [Reaction:R-CEL-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Caenorhabditis elegans [Reaction:R-DME-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Drosophila melanogaster [Reaction:R-GGA-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Gallus gallus [Reaction:R-SSC-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Sus scrofa [Reaction:R-BTA-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Bos taurus [Reaction:R-CFA-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Canis familiaris
output	5 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-8878073] p-S249,S273,S276-RUNX1:CBFB:p-S,T-EP300 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8878056] RUNX1:CBFB binds EP300 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8878050
summation	[Summation:8878080] HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300...
updateTrackers	[UpdateTracker:9846635] Update Tracker - [Reaction:8878050] HIPK2 phosphorylates RUNX1 and EP300 - v84:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846635] Update Tracker - [Reaction:8878050] HIPK2 phosphorylates RUNX1 and EP300 - v84:[modifyText]
(hasEvent)	[Pathway:R-HSA-8939243] RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known